Zhou Chaomin, Liu Zhigang, Sui Weiguo, Gu Dongfeng, Li Yongqiang, Zou Hequn
Institute of Nephrology and Urology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2014 Mar;34(3):419-22.
To explore the relationship between the major allergens of 6 common allergic foods and IgA nephropathy.
A sensitive sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of food-specific IgA1, IgG and IgE in 31 patients with IgA nephropathy and 80 healthy volunteers. All the patients were examined for a history of food allergy using a questionnaire.
Serum levels of IgA1 and IgG against the major allergens of the 6 common allergic foods were significantly higher in patients with IgA nephropathy than in healthy volunteers (P<0.05). There was no detectable food-specific IgE antibodies in the two groups. No patients had a clear history of food allergy. All the patients with increased IgG levels specific to 4 or more foods simultaneously had proteinuria.
Some foods especially the highly allergic ones may participate in the pathogenesis and progression of IgA nephropathy.
探讨6种常见过敏食物的主要过敏原与IgA肾病之间的关系。
采用灵敏的夹心酶联免疫吸附测定法（ELISA）检测31例IgA肾病患者和80名健康志愿者血清中食物特异性IgA1、IgG和IgE水平。所有患者均通过问卷调查了解食物过敏史。
IgA肾病患者血清中针对6种常见过敏食物主要过敏原的IgA1和IgG水平显著高于健康志愿者（P<0.05）。两组均未检测到食物特异性IgE抗体。所有患者均无明确的食物过敏史。同时对4种或更多食物IgG水平升高的所有患者均有蛋白尿。
某些食物尤其是高致敏性食物可能参与IgA肾病的发病机制和病情进展。
