Zuo X L, Li Y Q, Li W J, Guo Y T, Lu X F, Li J M, Desmond P V
Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, China.
Clin Exp Allergy. 2007 Jun;37(6):823-30. doi: 10.1111/j.1365-2222.2007.02727.x.
Post-prandial worsening of symptoms as well as adverse reactions to one or more foods are common in the patients with functional gastrointestinal diseases, such as irritable bowel syndrome (IBS) and functional dyspepsia (FD). However, the role played by true food allergy in the pathogenesis of these diseases is still controversial and there are no well-established tests to identify food allergy in this condition.
To investigate serum food antigen-specific IgG, IgE antibody and total IgE antibody titres in controls and patients with IBS and FD, and to correlate symptoms with the food antigen-specific IgG titres in IBS and FD patients.
Thirty-seven IBS patients, 28 FD patients and 20 healthy controls participated in this study. Serum IgG and IgE antibody titres to 14 common foods including beef, chicken, codfish, corn, crab, eggs, mushroom, milk, pork, rice, shrimp, soybean, tomatoes and wheat were analysed by ELISA. Serum total IgE titres were also measured. Last, symptomatology was assessed in the study. Results IBS patients had significantly higher titres of IgG antibody to crab (P=0.000), egg (P=0.000), shrimp (P=0.000), soybean (P=0.017) and wheat (P=0.004) than controls. FD patients had significantly higher titres of IgG antibody to egg (P=0.000) and soybean (P=0.017) than controls. The percentage of individuals with detectable positive food antigen-specific IgE antibodies of the three groups did not show any significant differences (P=0.971). There were no significant differences between IBS patients, FD patients and controls in the serum total IgE antibody titres (P=0.978). Lastly, no significant correlation was seen between symptom severity and serum food antigen-specific IgG antibody titres both in IBS and FD patients.
Serum IgG antibody titres to some common foods increased in IBS and FD patients compared to controls. But there is no significant correlation between symptom severity and elevated serum food antigen-specific IgG antibodies in these patients.
在功能性胃肠疾病患者中，如肠易激综合征（IBS）和功能性消化不良（FD），餐后症状加重以及对一种或多种食物的不良反应很常见。然而，真正的食物过敏在这些疾病发病机制中所起的作用仍存在争议，并且尚无成熟的检测方法来识别这种情况下的食物过敏。
研究IBS和FD患者及对照组血清食物抗原特异性IgG、IgE抗体和总IgE抗体滴度，并将IBS和FD患者的症状与食物抗原特异性IgG滴度进行关联分析。
37例IBS患者、28例FD患者和20名健康对照者参与本研究。采用酶联免疫吸附测定法（ELISA）分析血清中针对牛肉、鸡肉、鳕鱼、玉米、螃蟹、鸡蛋、蘑菇、牛奶、猪肉、大米、虾、大豆、番茄和小麦这14种常见食物的IgG和IgE抗体滴度。同时检测血清总IgE滴度。最后，对研究对象的症状进行评估。结果：IBS患者针对螃蟹（P = 0.000）、鸡蛋（P = 0.000）、虾（P = 0.000）、大豆（P = 0.017）和小麦（P = 0.004）的IgG抗体滴度显著高于对照组。FD患者针对鸡蛋（P = 0.000）和大豆（P = 0.017）的IgG抗体滴度显著高于对照组。三组中可检测到食物抗原特异性IgE抗体阳性的个体百分比无显著差异（P = 0.971）。IBS患者、FD患者和对照组的血清总IgE抗体滴度无显著差异（P = 0.978）。最后，IBS和FD患者的症状严重程度与血清食物抗原特异性IgG抗体滴度之间均无显著相关性。
与对照组相比，IBS和FD患者血清中针对某些常见食物的IgG抗体滴度升高。但这些患者的症状严重程度与血清食物抗原特异性IgG抗体升高之间无显著相关性。
