[基质金属蛋白酶2过表达在子宫内膜腺癌中的临床意义]
[Clinical significance of MMP2 overexpression in endometrial adenocarcinoma].
作者信息
Li Shujun, Shen Xiang, Yang Zhixiong, Wu Aibing, Tang Zhi, Li Mingchun, Ling Yingxia
机构信息
Tumor Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China. E-mail:
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2014 Mar;34(3):423-5.
OBJECTIVE
To explore the expression of MMP2 and its correlation with the clinical features and prognosis of endometrial adenocarcinoma.
METHODS
We collected paraffin-embedded samples from 81 patients with endometrial adenocarcinoma aged 32 to 80 years to examine the expression of MMP2 using immunohistochemistry. The correlation of MMP2 expression with the clinical characteristics and prognosis of the patients was analyzed.
RESULTS
MMP2 protein was expressed in the cytoplasm of the tumor cells. MMP2 over-expression was negatively correlated with tumor differentiation (P=0.015) and prognosis (P=0.041) of endometrial adenocarcinoma.
CONCLUSION
MMP2 over-expression is a potential malignant biomarker in endometrial adenocarcinoma.
目的
探讨基质金属蛋白酶2（MMP2）的表达及其与子宫内膜腺癌临床特征和预后的相关性。
方法
收集81例年龄在32至80岁的子宫内膜腺癌患者的石蜡包埋样本，采用免疫组织化学法检测MMP2的表达。分析MMP2表达与患者临床特征及预后的相关性。
结果
MMP2蛋白在肿瘤细胞的细胞质中表达。MMP2过表达与子宫内膜腺癌的肿瘤分化（P = 0.015）和预后（P = 0.041）呈负相关。
结论
MMP2过表达是子宫内膜腺癌潜在的恶性生物标志物。
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