接受抗逆转录病毒治疗的患者中异烟肼预防性治疗的使用：一个被错失的机会。

Isoniazid preventive therapy use among patients on antiretroviral therapy: a missed opportunity.

作者信息

Kufa T, Chihota V N, Charalambous S, Churchyard G J

机构信息

The Aurum Institute, Johannesburg, South Africa; School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

出版信息

Int J Tuberc Lung Dis. 2014 Mar;18(3):312-4. doi: 10.5588/ijtld.13.0505.

DOI:10.5588/ijtld.13.0505

PMID:24670568

Abstract

Isoniazid preventive therapy (IPT) with antiretroviral therapy (ART) reduces incident tuberculosis among patients infected with the human immunodeficiency virus. We describe IPT use among patients on ART at two primary care clinics in South Africa. Of 597 participants interviewed, 100 (16.8%) reported IPT use; 73.4% (365/497) with no reported IPT use were eligible for IPT. IPT use was associated with age <35 years (aOR 1.90, 95%CI 1.18-3.06), and receiving care at one clinic as opposed to the other (aOR 4.72, 95%CI 2.69-7.93). The high proportion of patients on ART eligible for IPT represents a missed opportunity for IPT scale-up.

摘要

异烟肼预防性治疗（IPT）联合抗逆转录病毒治疗（ART）可降低人类免疫缺陷病毒感染者的结核病发病率。我们描述了南非两家初级保健诊所接受ART治疗的患者中IPT的使用情况。在接受访谈的597名参与者中，100名（16.8%）报告使用了IPT；497名未报告使用IPT的参与者中有73.4%（365/497）符合IPT使用条件。IPT的使用与年龄<35岁（调整后比值比[aOR]为1.90，95%置信区间[CI]为1.18 - 3.06）以及在其中一家诊所而非另一家接受治疗有关（aOR为4.72，95%CI为2.69 - 7.93）。符合IPT使用条件的接受ART治疗患者比例较高，这代表了扩大IPT使用规模的一个错失机遇。