*Lovelace Respiratory Research Institute, Albuquerque, NM; †State University of Rio de Janeiro, Brazil; ‡Oak Ridge National Laboratory, TN; §Los Alamos National Laboratory, Los Alamos, NM.
Health Phys. 2014 May;106(5):592-7. doi: 10.1097/HP.0000000000000035.
Prussian blue (PB) is an efficient drug for enhancing cesium elimination from the body. Literature data on the efficacy of PB treatment in dosages that vary from 1-10 g d was reviewed. Cesium biokinetics was simulated using a detailed systemic biokinetic model. The same model was used to simulate the maximum action of PB by interrupting the enterohepatic circulation. Model results reproduced reasonably well the literature data on the efficacy of PB administered to humans after incidental cesium intakes, as well as results from animal experiments. Maximum efficiency of the reduction of the long-term half-time is obtained with the administration of 3 g d PB to the adult. Maximum efficiency of reducing the Cs body burdens is obtained when PB is administered on the first day after the intake, due to the increase of the short-term elimination of cesium. The model predicts that reduction of the long-term half-life is not affected by the time after intake that PB is administered, as long as it is given within the interval from 1 h to 1 y after the intake.
普鲁士蓝（PB）是一种有效药物，可促进体内铯的排出。本文回顾了剂量在 1-10g/d 范围内的 PB 治疗效果的文献数据。使用详细的全身生物动力学模型模拟铯的生物动力学。同样的模型被用于模拟通过中断肠肝循环来实现 PB 的最大作用。模型结果很好地再现了意外摄入铯后人类接受 PB 治疗的文献数据，以及动物实验的结果。对于成年人，每天给予 3g PB 可获得最长半衰期降低的最大效率。由于铯的短期排泄增加，在摄入后第一天给予 PB 可获得最大的 Cs 体负荷降低效率。该模型预测，只要在摄入后 1 小时至 1 年内给予 PB，其半衰期的延长不会受到给药时间的影响。
