Elliott H L, Meredith P A, Reid J L, Faulkner J K
University Department of Materia Medica, Stobhill General Hospital, Glasgow, Scotland.
J Cardiovasc Pharmacol. 1988;12 Suppl 7:S64-6. doi: 10.1097/00005344-198812007-00014.
The potential use of calcium antagonists in the treatment of hypertension and ischemic heart disease in elderly patients creates a requirement for pharmacokinetic information that is specific for that age group. This study describes the pharmacokinetics of amlodipine after single oral doses of 5 mg in 16 elderly subjects, mean age 72 years, age range 65-85 years. The principal findings were that the mean elimination half-life was 48 h and that peak plasma drug concentrations were not observed until 7 h after dosing. In comparison with data obtained from a group of young subjects, mean age 26 years, there were significant differences in pharmacokinetics. The terminal elimination half-life of 48 h in the elderly was significantly longer than that of 35 h in the young subjects and there was a correspondingly greater area under the curve in the elderly, by approximately 50%. These findings are consistent with an age-related reduction in drug clearance.
钙拮抗剂在老年患者高血压和缺血性心脏病治疗中的潜在应用，使得需要有针对该年龄组的药代动力学信息。本研究描述了16名老年受试者（平均年龄72岁，年龄范围65 - 85岁）单次口服5毫克氨氯地平后的药代动力学情况。主要研究结果为平均消除半衰期为48小时，给药后7小时才观察到血浆药物浓度峰值。与一组平均年龄26岁的年轻受试者所获得的数据相比，药代动力学存在显著差异。老年受试者48小时的终末消除半衰期显著长于年轻受试者的35小时，且老年受试者的曲线下面积相应地更大，约大50%。这些发现与药物清除率随年龄降低一致。
