Elliott H L, Green S T, Vincent J, Meredith P A
University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, UK.
Pharmacol Res. 1992 Jul-Aug;26(1):33-9. doi: 10.1016/1043-6618(92)90703-e.
This study characterizes the single dose pharmacokinetic characteristics of the dihydropyridine calcium antagonist drug amlodipine in a group of 16 elderly subjects, aged 65 to 86 years (8 M:8 F). The most notable pharmacokinetic features were a prolonged terminal elimination half life of 48 +/- 16 hours and a delayed tmax of 7.3 +/- 1.3 hours. Consistent with the time to achieve peak plasma drug concentrations, there was a modest but significant reduction in blood pressure at 6-8 hours after dosing. Comparison of these results with those of published data for young subjects indicate not only a greater degree of intersubject variability but also a longer half life in the elderly, suggestive of reduced drug clearance, which may lead to higher plasma drug concentrations particularly at steady state.
本研究对一组16名年龄在65至86岁之间（8名男性：8名女性）的老年受试者进行了二氢吡啶类钙拮抗剂药物氨氯地平的单剂量药代动力学特征研究。最显著的药代动力学特征是终末消除半衰期延长至48±16小时，达峰时间延迟至7.3±1.3小时。与达到血浆药物浓度峰值的时间一致，给药后6至8小时血压有适度但显著的下降。将这些结果与年轻受试者的已发表数据进行比较，不仅表明老年受试者个体间变异性更大，而且半衰期更长，提示药物清除率降低，这可能导致血浆药物浓度升高，尤其是在稳态时。
