Solak Özlem, Erdoğan Müjgan Özdemir, Yıldız Handan, Ulaşlı Alper Murat, Yaman Fatima, Terzi Evrim Suna Arıkan, Ulu Sena, Dündar Ümit, Solak Mustafa
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
Rheumatol Int. 2014 Sep;34(9):1257-61. doi: 10.1007/s00296-014-2995-1. Epub 2014 Mar 27.
Fibromyalgia may present with widespread pain and tenderness, fatigue, anxiety, and depression and is associated with a low pain threshold. The etiology of fibromyalgia is yet to be ascertained, although both genetic and environmental factors may play a role in the susceptibility of patients to fibromyalgia. Various genetic variations have been investigated to explain fibromyalgia susceptibility and differences in pain sensitivity, pain threshold, and tolerance. The A118G rs1799971 polymorphism in the opioid receptor μ1 gene (OPRM1) is one of the candidate genes. We hypothesized that the OPRM1 polymorphism may play a role in fibromyalgia susceptibility and impact the pain intensity and pain-related symptoms in fibromyalgia patients. This study comprised of 108 patients with fibromyalgia and 100 healthy controls. Overall, the 118G allele frequency was 16.3 % and was significantly lower in patients with fibromyalgia than in the control group (13.9 and 19 %, respectively). No difference was observed between fibromyalgia patients with and without the A118G allele with regard to the Beck Depression Inventory, widespread pain index, symptom severity, and Fibromyalgia Impact Questionnaire scores. All body parts of patients with fibromyalgia demonstrated lower pressure pain thresholds (PPT) compared to controls. The PPTs were higher in the 118 A/A genotype carrier fibromyalgia patients than in 118*/G carriers; however, the differences were not significant. As the A118G polymorphism frequency was lower in fibromyalgia patients, this polymorphism may exert a protective effect against fibromyalgia in Turkish women. However, the OPRM1 polymorphism does not have a significant effect on pressure pain and fibromyalgia severity.
纤维肌痛可能表现为广泛的疼痛和压痛、疲劳、焦虑和抑郁，且与疼痛阈值较低有关。尽管遗传和环境因素可能在患者对纤维肌痛的易感性中起作用，但纤维肌痛的病因尚未确定。人们已经研究了各种基因变异来解释纤维肌痛易感性以及疼痛敏感性、疼痛阈值和耐受性的差异。阿片受体μ1基因（OPRM1）中的A118G rs1799971多态性是候选基因之一。我们假设OPRM1多态性可能在纤维肌痛易感性中起作用，并影响纤维肌痛患者的疼痛强度和疼痛相关症状。本研究包括108例纤维肌痛患者和100名健康对照者。总体而言，118G等位基因频率为16.3%，纤维肌痛患者中的该频率显著低于对照组（分别为13.9%和19%）。在贝克抑郁量表、广泛疼痛指数、症状严重程度和纤维肌痛影响问卷得分方面，有和没有A118G等位基因的纤维肌痛患者之间未观察到差异。与对照组相比，纤维肌痛患者的所有身体部位均表现出较低的压痛阈值（PPT）。118 A/A基因型携带者纤维肌痛患者的PPT高于118*/G携带者；然而，差异不显著。由于纤维肌痛患者中A118G多态性频率较低，这种多态性可能对土耳其女性的纤维肌痛起到保护作用。然而，OPRM1多态性对压痛和纤维肌痛严重程度没有显著影响。
