Kaski Shane W, Brooks Stephan, Wen Sijin, Haut Marc W, Siderovski David P, Berry James H, Lander Laura R, Setola Vincent
Department of Physiology & Pharmacology, West Virginia University School of Medicine, Morgantown, WV.
Clarion University of Pennsylvania, Clarion, PA.
J Opioid Manag. 2019 Mar-Apr;15(2):103-109. doi: 10.5055/jom.2019.0491.
Pilot study to assess utility in opioid use disorder (OUD) of a panel of single nucleotide polymorphisms in genes previously related to substance use disorder (SUD) and/or phenotypes that predispose individuals to OUD/SUD.
Genetic association study.
West Virginia University's Chestnut Ridge Center Comprehensive Opioid Abuse Treatment (COAT) clinic for individuals diagnosed with OUD.
Sixty patients 18 years of age or older with OUD undergoing medication (buprenorphine/naloxone)-assisted treatment (MAT); all sixty patients recruited contributed samples for genetic analysis.
Minor allele frequencies for single nucleotide polymorphisms.
Four of the fourteen single nucleotide polymorphisms examined were present at frequencies that are statistically significantly different than in a demographically-matched general population.
For the purposes of testing WV individuals via genetic means for predisposition to OUD, at least four single nucleotide polymorphisms in three genes are likely to have utility in predicting susceptibility. Additional studies with larger populations will need to be conducted to confirm these results before use in a clinical setting.
进行一项试点研究，以评估一组单核苷酸多态性在阿片类物质使用障碍（OUD）中的效用，这些基因先前与物质使用障碍（SUD）和/或使个体易患OUD/SUD的表型相关。
基因关联研究。
西弗吉尼亚大学栗树岭中心综合阿片类药物滥用治疗（COAT）诊所，针对被诊断患有OUD的个体。
60名18岁及以上患有OUD且正在接受药物（丁丙诺啡/纳洛酮）辅助治疗（MAT）的患者；招募的所有60名患者均提供了用于基因分析的样本。
单核苷酸多态性的次要等位基因频率。
所检测的14个单核苷酸多态性中有4个的频率与人口统计学匹配的普通人群相比有统计学显著差异。
为了通过基因手段检测西弗吉尼亚州个体患OUD的易感性，三个基因中的至少四个单核苷酸多态性可能在预测易感性方面有用。在临床环境中使用之前，需要进行更多更大规模人群的研究来证实这些结果。
