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对113例接受手术治疗的脊椎椎间盘炎患者进行的回顾性研究。单中心经验。

A retrospective study of 113 consecutive cases of surgically treated spondylodiscitis patients. A single-center experience.

作者信息

Shiban Ehab, Janssen Insa, Wostrack Maria, Krieg Sandro M, Ringel Florian, Meyer Bernhard, Stoffel Michael

机构信息

Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany,

出版信息

Acta Neurochir (Wien). 2014 Jun;156(6):1189-96. doi: 10.1007/s00701-014-2058-0. Epub 2014 Mar 27.

Abstract

BACKGROUND

Recommendations for the operative treatment of spondylodiscitis are still a controversial issue.

METHODS

A retrospective review identified 113 consecutive patients who underwent surgical debridement and instrumentation for spondylodiscitis between 2006 and 2010 at our department.

RESULTS

The mean age at presentation was 65 years; 78 patients were male (69 %). Distribution of the inflammation was lumbar in 68 (60 %), thoracic in 19 (17 %) and cervical in 20 (18 %) cases. Six patients (5 %) had two concomitant non-contiguous spondylodiscitis foci in different segments of the spine. Epidural abscess was found in 33 patients (29 %). One hundred four patients (92 %) had pain. Neurological deficit was found in 40 patients (35 %). In the thoracic and lumbar cases, dorsal instrumentation alone was considered sufficient in 26 cases; additional interbody fusion from the posterior was performed in 44 cases. A 360° instrumentation was performed in 22 cases. In the cervical cases, only ventral spondylodesis and plating were performed in eight cases, only dorsal instrumentation in five and 360° instrumentation in seven. Postoperative intravenous antibiotics were administered for 14.4 ± 9.3 (mean ± SD) days followed by 3.2 ± 0.8 (mean ± SD) months of oral antibiosis. Complete healing of the inflammation was achieved in 111 (98 %) cases. Two patients died because of septic shock, both with fulminant endocarditis. Pain resolved in all cases. Neurological deficits were completely resolved in 20 patients, and 14 patients had a partial recovery.

CONCLUSION

The results of our retrospective study show that surgical treatment of spondylodiscitis with a staged surgical approach (if needed) and a short 1-2-week period of intravenous antibiotics followed by 3 months of oral antibiotics is appropriate for most patients in whom conservative treatment has failed or is not advisable. Furthermore, surgical treatment of newly diagnosed spondylodiscitis might be recommended as an initial treatment option in many cases. Thereby the choice of fusion material (autologous bone, titanium, PEEK) seems less important.

摘要

背景

脊椎椎间盘炎手术治疗的建议仍是一个有争议的问题。

方法

一项回顾性研究确定了2006年至2010年期间在我科连续接受脊椎椎间盘炎手术清创和内固定的113例患者。

结果

就诊时的平均年龄为65岁;78例患者为男性(69%)。炎症分布情况为:腰椎68例(60%),胸椎19例(17%),颈椎20例(18%)。6例患者(5%)在脊柱不同节段有两个不连续的脊椎椎间盘炎病灶。33例患者(29%)发现硬膜外脓肿。104例患者(92%)有疼痛。40例患者(35%)发现神经功能缺损。在胸椎和腰椎病例中,26例仅行后路内固定被认为足够;44例加做了后路椎间融合术。22例行360°内固定。在颈椎病例中,8例仅行前路椎体融合和钢板固定,5例仅行后路内固定,7例行360°内固定。术后静脉使用抗生素14.4±9.3(均值±标准差)天,随后口服抗生素3.2±0.8(均值±标准差)个月。111例(98%)炎症完全愈合。2例患者因感染性休克死亡,均患有暴发性心内膜炎。所有病例疼痛均缓解。20例患者神经功能缺损完全恢复,14例部分恢复。

结论

我们的回顾性研究结果表明,对于大多数保守治疗失败或不可行的患者,采用分期手术方法(如有需要)并短期静脉使用抗生素1 - 2周,随后口服抗生素3个月的脊椎椎间盘炎手术治疗是合适的。此外,在许多情况下,新诊断的脊椎椎间盘炎的手术治疗可能被推荐作为初始治疗选择。因此,融合材料(自体骨、钛、聚醚醚酮)的选择似乎不那么重要。

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