纤维蛋白凝块特性及其在血栓形成性疾病中的调节。
Fibrin clot properties and their modulation in thrombotic disorders.
作者信息
Undas A
机构信息
Anetta Undas, MD, PhD, Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St., 31-202 Krakow, Poland, Tel.: +48 12 6143004, Fax: +48 12 4233900, E-mail:
出版信息
Thromb Haemost. 2014 Jul 3;112(1):32-42. doi: 10.1160/TH14-01-0032. Epub 2014 Mar 27.
Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clot structure and function in patients with various thromboembolic manifestations, in particular myocardial infarction, ischaemic stroke and venous thromboembolism, based on the publications till December 2013. Moreover, factors will be presented that in vivo unfavourably determine altered fibrin clot properties in thrombotic disorders and modalities that can improve clot phenotype.
越来越多的证据表明，在静脉或动脉血栓形成的患者中，通常可以观察到由紧密、高度分支的网络和相对抗纤溶酶介导溶解的细纤维组成的纤维蛋白凝块加速形成。基于截至2013年12月的出版物，本综述讨论了各种血栓栓塞表现患者的纤维蛋白凝块结构和功能特征，特别是心肌梗死、缺血性中风和静脉血栓栓塞。此外，还将介绍在体内不利地决定血栓形成疾病中纤维蛋白凝块特性改变的因素以及可以改善凝块表型的方式。
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