Lambert Jérémy, Hansen Brian B, Arnould Benoit, Grataloup Géraldine, Guillemin Isabelle, Højbjerre Lise, Strandberg-Larsen Martin, Reilly Margaret C
Mapi, HEOR and Strategic Market Access, 27, Rue de la Villette, 69003, Lyon, France.
Patient. 2014;7(2):171-6. doi: 10.1007/s40271-014-0053-4.
Impairments in work productivity and daily activities contribute to the burden of rheumatoid arthritis (RA). It is thus essential to use an instrument assessing both work and daily activity impairments when studying the full impact of RA on individuals. The Work Productivity and Activity Impairment (WPAI) questionnaire is such an instrument.
This study aims to linguistically validate the RA-specific WPAI (WPAI:RA) instrument in 20 new languages and to assess its content validity for individuals with RA.
The linguistic validation of the questionnaire followed a standard methodology that included comprehension test interviews (n = 5 individuals with RA per language) to assess the relevance, understanding and acceptability of the WPAI:RA. Content validity of the instrument was simultaneously investigated.
Comprehension testing showed that the WPAI:RA questionnaire was well understood similarly across countries; minor changes were made to ensure fidelity to the original concepts and for ease of comprehension. The majority of interviewees (66/93) considered its content comprehensive and appropriate to measure their ability to work and perform daily activities.
The WPAI:RA questionnaire is now linguistically validated in 20 new languages [Czech (Czech Republic), Dutch (Belgium), English (Canada and UK), French (Belgium, Canada and France), German (Germany), Hungarian (Hungary), Italian (Italy), Polish (Poland), Portuguese (Brazil), Romanian (Romania), Russian (Russia and Ukraine), Spanish (Argentina, Mexico, Spain and US) and Ukrainian (Ukraine)]. The WPAI:RA questionnaire shows good content validity. It can thus be used in multi-country clinical trials to assess RA-related impact on the patients' ability to work and perform daily activities.
工作效率和日常活动受损加重了类风湿关节炎（RA）的负担。因此，在研究RA对个体的全面影响时，使用一种能够同时评估工作和日常活动受损情况的工具至关重要。工作效率与活动受损（WPAI）问卷就是这样一种工具。
本研究旨在对20种新语言的RA特异性WPAI（WPAI:RA）工具进行语言验证，并评估其对RA患者的内容效度。
问卷的语言验证遵循标准方法，包括理解测试访谈（每种语言n = 5名RA患者），以评估WPAI:RA的相关性、易懂性和可接受性。同时对该工具的内容效度进行了调查。
理解测试表明，WPAI:RA问卷在各国的理解程度相似；进行了细微修改以确保忠实于原始概念并便于理解。大多数受访者（66/93）认为其内容全面，适合衡量他们的工作能力和进行日常活动的能力。
WPAI:RA问卷现已在20种新语言中进行了语言验证[捷克语（捷克共和国）、荷兰语（比利时）、英语（加拿大和英国）、法语（比利时、加拿大和法国）、德语（德国）、匈牙利语（匈牙利）、意大利语（意大利）、波兰语（波兰）、葡萄牙语（巴西）、罗马尼亚语（罗马尼亚）、俄语（俄罗斯和乌克兰）、西班牙语（阿根廷、墨西哥、西班牙和美国）和乌克兰语（乌克兰）]。WPAI:RA问卷显示出良好的内容效度。因此，它可用于多国临床试验，以评估RA对患者工作能力和进行日常活动能力的相关影响。
