类风湿关节炎临床缓解患者的患者报告结局与工作和活动障碍的相关性：使用 IORRA 数据库的回顾性分析。

Association between patient-reported outcomes and impairments in work and activity in patients with rheumatoid arthritis in clinical remission: A retrospective analysis using the IORRA database.

机构信息

Department of Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.

Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.

出版信息

Mod Rheumatol. 2023 Aug 25;33(5):899-905. doi: 10.1093/mr/roac105.

DOI:10.1093/mr/roac105

PMID:36094815

Abstract

OBJECTIVES

To explore the patient-reported outcomes (PROs) associated with work productivity and activity impairment (WPAI) in patients with rheumatoid arthritis (RA) in clinical remission.

METHODS

We enrolled patients with RA ≥18 years and with a simplified disease activity index ≤3.3 from the Institute of Rheumatology, Rheumatoid Arthritis data set collected in October 2017. The pain-visual analogue scale, patients' global assessment visual analogue scale (VAS), Japanese version of the Healthcare Assessment Questionnaire (J-HAQ) Disability Index, and duration of morning joint stiffness were selected as the PROs. To evaluate work productivity and activity, the WPAI for RA instrument (WPAI-RA) was used. To assess the contribution of each PRO to the WPAI-RA score, an analysis of variance model was constructed.

RESULTS

The mean age of the 2614 patients was 62.4 years; 85.1% were female. Median values of the WPAI-RA score were 1.1% for absenteeism, 6.5% for presenteeism, 7.4% for work impairment, and 10.2% for activity impairment. Morning joint stiffness contributed the most to absenteeism (18.0%), while pain-VAS contributed the most to presenteeism (57.4%), work productivity loss (51.1%), and daily activity impairment (53.7%). J-HAQ was the second most contributing factor to presenteeism (17.4%), work productivity loss (16.3%), and daily activity impairment (26.0%).

CONCLUSIONS

The pain-VAS and J-HAQ highly contributed to WPAI in patients with RA in clinical remission.

摘要

目的

探讨类风湿关节炎（RA）临床缓解患者与工作生产力和活动损伤（WPAI）相关的患者报告结局（PRO）。

方法

我们纳入了来自 2017 年 10 月收集的风湿病研究所 RA 数据集中≥18 岁且简化疾病活动指数≤3.3 的 RA 患者。疼痛视觉模拟量表、患者总体评估视觉模拟量表（VAS）、日本版健康评估问卷（J-HAQ）残疾指数和晨僵持续时间被选为 PRO。为了评估工作生产力和活动，使用 RA 患者工作生产力和活动评估工具（WPAI-RA）。为了评估每个 PRO 对 WPAI-RA 评分的贡献，构建了方差分析模型。

结果

2614 例患者的平均年龄为 62.4 岁，85.1%为女性。WPAI-RA 评分的中位数分别为缺勤率为 1.1%，在职病假率为 6.5%，工作损伤率为 7.4%，活动损伤率为 10.2%。晨僵持续时间对缺勤的贡献最大（18.0%），而疼痛 VAS 对在职病假（57.4%）、工作生产力损失（51.1%）和日常活动损伤（53.7%）的贡献最大。J-HAQ 是在职病假（17.4%）、工作生产力损失（16.3%）和日常活动损伤（26.0%）的第二大贡献因素。