外阴癌的预后与淋巴结状态及原发灶大小：一项生存研究。
Prognosis of vulval cancer with lymph node status and size of primary lesion: A survival study.
作者信息
Deka Pankaj, Barmon Debabrata, Shribastava Sushrata, Kataki Amal Chandra, Sharma J D, Bhattacharyya M
机构信息
Department of Gynaecological Oncology, Dr. Bhubaneswar Borooah Cancer Institute, Guwahati, Assam, India.
Department of Pathology, Dr. Bhubaneswar Borooah Cancer Institute, Guwahati, Assam, India.
出版信息
J Midlife Health. 2014 Jan;5(1):10-3. doi: 10.4103/0976-7800.127784.
INTRODUCTION
Squamous cell cancer of the vulva is a rare disease with an annual incidence of two to three per 100,000 women. Lymph node metastasis is the most important prognostic factor for the recurrence and survival in vulval carcinoma.
MATERIALS AND METHODS
It is a retrospective study of 18 cases, operated in our institute from 2006 to 2009 and followed up till July, 2012. These patients were divided into two group of node positive and node negative and compared for recurrence and survival.
RESULT
Ten patients had lymph node metastasis and eight had no lymph node metastasis. Recurrence rate was 40% and 12.5% in node positive and negative groups, respectively. Adjuvant radiation when given to node negative bulky tumor showed no recurrence compared to one out of two in the non-irradiated group. Survival was only 25% in node positive recurrent cases.
CONCLUSION
Lymph node positivity added a great risk for future recurrence. Prophylactic radiation in node negative, bulky tumor is helpful.
引言
外阴鳞状细胞癌是一种罕见疾病，每10万名女性中的年发病率为2至3例。淋巴结转移是外阴癌复发和生存的最重要预后因素。
材料与方法
这是一项对18例病例的回顾性研究，这些病例于2006年至2009年在我们研究所接受手术，并随访至2012年7月。这些患者被分为淋巴结阳性组和淋巴结阴性组，并比较其复发率和生存率。
结果
10例患者有淋巴结转移，8例无淋巴结转移。淋巴结阳性组和阴性组的复发率分别为40%和12.5%。对于淋巴结阴性的大块肿瘤，给予辅助放疗的患者无复发，而未接受放疗的两组中有一组出现1例复发。淋巴结阳性复发病例的生存率仅为25%。
结论
淋巴结阳性大大增加了未来复发的风险。对淋巴结阴性的大块肿瘤进行预防性放疗是有帮助的。
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