绝经后女性的阿尔茨海默病：在关键窗口期进行干预。
Alzheimer disease in post-menopausal women: Intervene in the critical window period.
作者信息
Jamshed Nayer, Ozair Fouzia Firdaus, Aggarwal Praveen, Ekka Meera
机构信息
Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India.
Department of Forensic Medicine, Hamdard Institute of Medical Sciences and Research, New Delhi, India.
出版信息
J Midlife Health. 2014 Jan;5(1):38-40. doi: 10.4103/0976-7800.127791.
Abstract
Alzheimer disease (AD) is a crippling neurodegenerative disorder. It is more common in females after menopause. Estrogen probably has a protective role in cognitive decline. Large amount of research has been carried out to see the benefits of hormone replacement therapy with regards to Alzheimer still its neuroprotective effect is not established. Recent studies suggest a reduced risk of AD and improved cognitive functioning of post-menopausal women who used 17 β-estradiol in the critical period. Use of 17 β-estradiol in young and healthy post-menopausal women yields the maximum benefit when the neurons are intact or neuronal stress has just started. Hence intervention in the critical period is key in the prevention or delay of AD in post-menopausal women.
摘要
阿尔茨海默病（AD）是一种致残性神经退行性疾病。它在绝经后女性中更为常见。雌激素可能在认知衰退中具有保护作用。关于阿尔茨海默病，已经进行了大量研究以探讨激素替代疗法的益处，但其神经保护作用尚未确立。最近的研究表明，在关键时期使用17β-雌二醇的绝经后女性患AD的风险降低，认知功能得到改善。在年轻健康的绝经后女性中，当神经元完整或神经元应激刚刚开始时使用17β-雌二醇可产生最大益处。因此，在关键时期进行干预是预防或延缓绝经后女性AD的关键。
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