Sen Rituparno, Ghosal Suman, Das Shaoli, Balti Subrata, Chakrabarti Jayprokas
Gyanxet, BF 286 Salt Lake, Kolkata, West Bengal 700064, India.
Indian Association for the Cultivation of Science, Kolkata, West Bengal 700032, India.
ScientificWorldJournal. 2014 Feb 2;2014:896206. doi: 10.1155/2014/896206. eCollection 2014.
Competing endogenous RNA, ceRNA, vie with messenger RNAs (mRNAs) for microRNAs (miRNAs) with shared miRNAs responses elements (MREs) and act as modulator of miRNA by influencing the available level of miRNA. It has recently been discovered that, apart from protein-coding ceRNAs, pseudogenes, long noncoding RNAs (lncRNAs), and circular RNAs act as miRNA "sponges" by sharing common MRE, inhibiting normal miRNA targeting activity on mRNA. These MRE sharing elements form the posttranscriptional ceRNA network to regulate mRNA expression. ceRNAs are widely implicated in many biological processes. Recent studies have identified ceRNAs associated with a number of diseases including cancer. This brief review focuses on the molecular mechanism of ceRNA as part of the complex post-transcriptional regulatory circuit in cell and the impact of ceRNAs in development and disease.
竞争性内源RNA（ceRNA）与信使RNA（mRNA）竞争具有共享微小RNA反应元件（MRE）的微小RNA（miRNA），并通过影响miRNA的可利用水平来充当miRNA的调节剂。最近发现，除了蛋白质编码ceRNA外，假基因、长链非编码RNA（lncRNA）和环状RNA通过共享共同的MRE充当miRNA“海绵”，抑制miRNA对mRNA的正常靶向活性。这些MRE共享元件形成转录后ceRNA网络以调节mRNA表达。ceRNA广泛参与许多生物学过程。最近的研究已经鉴定出与包括癌症在内的多种疾病相关的ceRNA。本简要综述重点关注ceRNA作为细胞中复杂转录后调控回路一部分的分子机制以及ceRNA在发育和疾病中的影响。
