Haeuber D, DiJulio J E
Oncol Nurs Forum. 1989 Mar-Apr;16(2):247-55.
Hemopoiesis is the process by which the various blood cell lineages proliferate, differentiate, and mature. Colony stimulating factors (CSFs) are a group of glycoproteins that are extensively involved in hemopoiesis at every level. In recent years, a number of these agents have been identified. They now are being produced in large enough quantities to make possible the in-depth exploration not only of their functions but, more importantly from a clinical perspective, of their therapeutic potential. This article reviews the role of the CSFs in hemopoiesis and summarizes some of the current research concerning their therapeutic applications. In particular, it emphasizes the CSFs involved in granulopoiesis and their uses in hematology/oncology patient populations.
造血是各种血细胞谱系增殖、分化和成熟的过程。集落刺激因子（CSF）是一组糖蛋白，在造血的各个层面广泛参与其中。近年来，已鉴定出多种此类因子。它们现在的产量足以使人们不仅能够深入探索其功能，而且从临床角度更重要的是能够深入探索其治疗潜力。本文综述了CSF在造血中的作用，并总结了目前有关其治疗应用的一些研究。特别是，它强调了参与粒细胞生成的CSF及其在血液学/肿瘤学患者群体中的用途。
