Nemes-Nikodém E, Vörös E, Pónyai K, Párducz L, Kárpáti S, Rozgonyi F, Ostorházi E
Semmelweis University Budapest Hungary.
Eur J Microbiol Immunol (Bp). 2012 Jun;2(2):157-60. doi: 10.1556/EuJMI.2.2012.2.9. Epub 2012 Jun 13.
From January 1, 2009 through December 31, 2011, from 33,753 blood samples for syphilis screening, Treponema pallidum infections were confirmed in 241 pregnant women at the Department of Dermatology, Venerology, and Dermatooncology of Semmelweis University Budapest. In this period, four children born to inadequately or untreated women were confirmed to have connatal syphilis. The height of rapid plasma reagin (RPR) titer was measured to determine the stage of the infection and to examine the success of the antilues therapy. The diagnosis of maternal syphilis infection was confirmed with enzyme linked immunosorbent assay (ELISA), T. pallidum particle agglutination (TPPA), and IgG and IgM immunoblots. Maternal IgM immunoblot results identify mothers at risk of delivering babies with connatal syphilis better than the height of maternal RPR titer. The standard serological tests are less useful in newborns because of IgG transfer across the placenta. IgM test which depends on the infant's response has more specificity in diagnosing connatal syphilis.
从2009年1月1日至2011年12月31日，在布达佩斯塞梅尔维斯大学皮肤病、性病与皮肤肿瘤学系，对33753份用于梅毒筛查的血样进行检测，确诊241名孕妇感染梅毒螺旋体。在此期间，证实4名由未充分治疗或未治疗的女性所生的儿童患有先天性梅毒。检测快速血浆反应素（RPR）滴度水平，以确定感染阶段并评估抗梅毒治疗的效果。采用酶联免疫吸附测定（ELISA）、梅毒螺旋体颗粒凝集试验（TPPA）以及IgG和IgM免疫印迹法确诊孕妇梅毒感染。孕妇IgM免疫印迹结果在识别有分娩先天性梅毒患儿风险的母亲方面，比孕妇RPR滴度水平更具优势。由于IgG可经胎盘转移，标准血清学检测对新生儿的诊断价值较小。依赖婴儿自身反应的IgM检测在诊断先天性梅毒方面具有更高的特异性。
