Laboratory of Experimental Immunology, BioMediTech, University of Tampere, Tampere, Finland.
Scand J Immunol. 2014 Jun;79(6):377-85. doi: 10.1111/sji.12170.
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway controls multiple biological processes in metazoan development and tissue homoeostasis. This creates a need for tight regulatory mechanisms to ensure proper responses. The core components of the pathway, as well as many of the regulatory molecules, are conserved in evolution and thus share similarities in organisms such as humans and fruit flies. Therefore, the fruit fly provides an amenable model system for elucidating the in vivo roles of the JAK/STAT pathway and its regulators, which are challenging to demonstrate in mammalian systems. This review will focus on describing recent advances in understanding the importance of JAK/STAT signalling in Drosophila immunity.
Janus 激酶/信号转导子和转录激活子（JAK/STAT）信号通路控制后生动物发育和组织内稳态中的多种生物学过程。这就需要有严格的调控机制来确保适当的反应。该途径的核心成分以及许多调节分子在进化中是保守的，因此在人类和果蝇等生物中存在相似性。因此，果蝇为阐明 JAK/STAT 途径及其调节剂在体内的作用提供了一种可行的模型系统，而这些在哺乳动物系统中很难证明。这篇综述将重点描述在理解 JAK/STAT 信号在果蝇免疫中的重要性方面的最新进展。
