胶体系统的加速稳定性试验（ASA）

Accelerated stability assay (ASA) for colloidal systems.

作者信息

Chong Josephine Y T, Mulet Xavier, Boyd Ben J, Drummond Calum J

机构信息

CSIRO Materials Science and Engineering , Private Bag 10, Clayton, Victoria 3169, Australia.

出版信息

ACS Comb Sci. 2014 May 12;16(5):205-10. doi: 10.1021/co400155y. Epub 2014 Apr 24.

DOI:10.1021/co400155y

PMID:24673241

Abstract

Assessment of the stability of colloidal systems, in particular lyotropic liquid crystalline dispersions, such as cubosomes and hexosomes, is typically performed qualitatively or with limited throughput on specialized instruments. Here, an accelerated stability assay for colloidal particles has been developed in 384-well plates with standard laboratory equipment. These protocols enable quantitative assessments of colloidal stability. To demonstrate the applicability of the assay, several steric stabilizers for cubic phase nanostructured particles (cubosomes) have been compared to the current "gold standard" Pluronic F127.

摘要

对胶体系统，特别是溶致液晶分散体（如立方相液晶纳米粒和六方相液晶纳米粒）稳定性的评估，通常是在专门仪器上进行定性评估或低通量评估。在此，利用标准实验室设备在384孔板中开发了一种用于胶体颗粒的加速稳定性测定法。这些方案能够对胶体稳定性进行定量评估。为证明该测定法的适用性，已将几种用于立方相纳米结构颗粒（立方相液晶纳米粒）的空间稳定剂与当前的“金标准”普朗尼克F127进行了比较。