Photobiology Unit, Dermatology Centre, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, M6 8HD, U.K.
Br J Dermatol. 2014 Aug;171(2):370-5. doi: 10.1111/bjd.13003. Epub 2014 Jul 30.
Photoprotection including sunscreen use in children is encouraged by health campaigns. While sunscreen chemicals are common causes of photoallergic (PA) contact reactions in adults, limited data are available in children.
To assess the frequency of PA and contact allergy (CA) to sunscreens in children aged < 18 years undergoing investigation for suspected photosensitivity.
Retrospective analysis of data on children who underwent photopatch testing to a standard series of nine ultraviolet (UV) filters and to sunscreen products in a single photoinvestigation centre (2000-11). Duplicate series of UV filters and the children's own sunscreen products were applied to the back, with readings taken at sample removal, and at 24 and 48 h after 5 J cm(-2) UVA exposure of one series.
The analysis comprised 157 children (aged 3-17 years, 69 male and 88 female). In total 10 children (6·4%) showed positive photopatch responses to UV filters and/or their sunscreen products (4·5% to UV filters, 5·7% to their sunscreen products). The responsible UV filters most often identified were benzophenone-3 and octyl methoxycinnamate. Additionally, CA reactions were observed in nine children (5·7%), with 16 children (10·2%) showing PA and/or CA to UV filters and/or sunscreen products.
This is the largest series of photopatch testing reported in children, and shows that both sunscreen PA and CA are quite frequent in those undergoing photoinvestigation. Photopatch testing should be considered in children presenting with features of photosensitivity.
健康宣传鼓励包括儿童在内的使用防晒霜进行光保护。虽然防晒霜化学物质是成人光变应性（PA）接触反应的常见原因，但儿童的数据有限。
评估接受疑似光敏性调查的<18 岁儿童中 PA 和接触性过敏（CA）对防晒霜的频率。
对在单一光过敏研究中心（2000-11 年）接受光斑贴试验的儿童进行回顾性数据分析，该试验采用了标准的九种紫外线（UV）滤光片系列和防晒霜产品。将重复系列的 UV 滤光片和儿童自己的防晒霜产品应用于背部，在样品去除时、在 24 和 48 小时后进行读数，然后在 5 J/cm(-2)UVA 暴露于一个系列后进行。
分析包括 157 名儿童（年龄 3-17 岁，69 名男性和 88 名女性）。共有 10 名儿童（6.4%）对 UV 滤光片和/或其防晒霜产品显示出阳性光斑贴反应（4.5%对 UV 滤光片，5.7%对其防晒霜产品）。最常鉴定出的负责 UV 滤光片是二苯甲酮-3 和辛基甲氧基肉桂酸酯。此外，在 9 名儿童（5.7%）中观察到 CA 反应，16 名儿童（10.2%）对 UV 滤光片和/或防晒霜产品显示出 PA 和/或 CA。
这是儿童中报告的最大光斑贴试验系列，表明接受光调查的儿童中，防晒霜 PA 和 CA 都相当常见。对于出现光敏性特征的儿童，应考虑进行光斑贴试验。
