Prox1、D2-40和WT1在梭形细胞血管瘤中的表达。
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma.
作者信息
Wang Lei, Gao Tianwen, Wang Gang
机构信息
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China.
出版信息
J Cutan Pathol. 2014 May;41(5):447-50. doi: 10.1111/cup.12309. Epub 2014 Mar 7.
BACKGROUND
Spindle cell hemangioma is a benign vascular proliferation that usually occurs on acral sites. A recent report showed focal positive staining of Prox1 in spindle cell hemangioma.
METHODS
We performed an immunohistochemical study of spindle cell hemangioma with antibodies to CD31, D2-40, Prox1, smooth muscle actin (SMA) and Wilms tumor-1 (WT-1).
RESULTS
The endothelial cells in spindle cell hemangioma were positive for CD31 and Prox1, focally positive for D2-40 and negative for WT-1, whereas the myoid spindle cells around the endothelial cells were weakly positive for WT-1.
CONCLUSION
Our results suggest that spindle cell hemangioma is a lymphatic malformation.
背景
梭形细胞血管瘤是一种通常发生于肢体末端部位的良性血管增生性病变。最近一项报告显示，梭形细胞血管瘤中Prox1呈局灶性阳性染色。
方法
我们运用抗CD31、D2-40、Prox1、平滑肌肌动蛋白（SMA）和肾母细胞瘤-1（WT-1）的抗体对梭形细胞血管瘤进行了免疫组织化学研究。
结果
梭形细胞血管瘤中的内皮细胞CD31和Prox1呈阳性，D2-40呈局灶性阳性，WT-1呈阴性，而内皮细胞周围的肌样梭形细胞WT-1呈弱阳性。
结论
我们的结果提示梭形细胞血管瘤是一种淋巴管畸形。
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