在温和条件下，通过有机催化方法实现异色满的 C(sp3)-H 键芳基化、烷基化和酰胺化反应。
Organocatalytic approach for C(sp3)-H bond arylation, alkylation, and amidation of isochromans under facile conditions.
机构信息
Graduate School of Biomedical Sciences, Nagasaki University , 1-14 Bunkyo-machi, Nagasaki, Nagasaki 852-8521, Japan.
出版信息
Org Lett. 2014 Apr 4;16(7):2042-5. doi: 10.1021/ol5006399. Epub 2014 Mar 27.
PMID:24673439
Abstract
A new catalytic approach for the synthesis of isochroman derivatives via direct C(sp(3))-H bond arylation is described. The oxidation reaction with [bis(trifluoroacetoxy)iodo]benzene facilitates the regeneration of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in the C(sp(3))-H bond arylation of isochroman. The reaction conditions can also be used for alkyl Grignard reagents and amides to afford the corresponding isochroman derivatives.
摘要
本文描述了一种通过直接 C(sp(3))-H 键芳基化合成异色满衍生物的新催化方法。用[双(三氟乙酰氧基)碘]苯进行氧化反应，有利于在异色满的 C(sp(3))-H 键芳基化中再生 2,3-二氯-5,6-二氰-1,4-苯醌。该反应条件也可用于烷基格氏试剂和酰胺，以得到相应的异色满衍生物。
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