Ozdemir Pinar Guzel, Karadag Ayşe Serap, Selvi Yavuz, Boysan Murat, Bilgili Serap Gunes, Aydin Adem, Onder Sevda
Department of Psychiatry, Yuzuncu Yil University Medicine Faculty , Van , Turkey.
Int J Psychiatry Clin Pract. 2014 Aug;18(3):161-8. doi: 10.3109/13651501.2014.907919. Epub 2014 Apr 23.
There are limited comparative studies on classic and new-generation antihistamines that affect sleep quality and mood. The purpose of this study was to determine and compare the effects of classic and new-generation antihistamines on sleep quality, daytime sleepiness, dream anxiety, and mood.
Ninety-two patients with chronic pruritus completed study in the dermatology outpatient clinic. Treatments with regular recommended therapeutic doses were administered. The effects of antihistaminic drugs on mood, daytime sleepiness, dream anxiety, and sleep quality were assessed on the first day and 1 month after.
Outpatients who received cetirizine and hydroxyzine treatments reported higher scores on the depression, anxiety, and fatigue sub-scales than those who received desloratadine, levocetirizine, and rupatadine. Pheniramine and rupatadine were found to be associated with daytime sleepiness and better sleep quality. UKU side effects scale scores were significantly elevated among outpatients receiving pheniramine. Classic antihistamines increased daytime sleepiness and decreased the sleep quality scores. New-generation antihistamines reduced sleep latency and dream anxiety, and increased daytime sleepiness and sleep quality.
Both antihistamines, significantly increased daytime sleepiness and nocturnal sleep quality. Daytime sleepiness was significantly predicted by rupadatine and pheniramine treatment. Cetirizine and hydroxyzine, seem to have negative influences on mood states. Given the extensive use of antihistamines in clinical settings, these results should be more elaborately examined in further studies.
关于影响睡眠质量和情绪的经典抗组胺药与新一代抗组胺药的比较研究有限。本研究的目的是确定并比较经典抗组胺药与新一代抗组胺药对睡眠质量、日间嗜睡、梦境焦虑和情绪的影响。
92例慢性瘙痒患者在皮肤科门诊完成研究。采用常规推荐治疗剂量进行治疗。在第一天和1个月后评估抗组胺药物对情绪、日间嗜睡、梦境焦虑和睡眠质量的影响。
接受西替利嗪和羟嗪治疗的门诊患者在抑郁、焦虑和疲劳子量表上的得分高于接受地氯雷他定、左西替利嗪和卢帕他定的患者。发现苯海拉明和卢帕他定与日间嗜睡和更好的睡眠质量有关。接受苯海拉明治疗的门诊患者UKU副作用量表得分显著升高。经典抗组胺药增加日间嗜睡并降低睡眠质量得分。新一代抗组胺药减少睡眠潜伏期和梦境焦虑，并增加日间嗜睡和睡眠质量。
两种抗组胺药均显著增加日间嗜睡和夜间睡眠质量。卢帕他定和苯海拉明治疗可显著预测日间嗜睡。西替利嗪和羟嗪似乎对情绪状态有负面影响。鉴于抗组胺药在临床环境中的广泛使用，这些结果应在进一步研究中进行更详细的检查。
