人群中杀伤细胞免疫球蛋白样受体（KIR）基因多态性与强直性脊柱炎的关联：一项荟萃分析。

Association between KIR polymorphisms and ankylosing spondylitis in populations: a meta-analysis.

作者信息

Fan Dazhi, Liu Si, Yang Ting, Wu Shanshan, Wang Sheng, Li Guixing, Zeng Zhen, Duan Zhenhua, Xia Guo, Ye Dongqing, Zou Yanfeng, Xu Shengqian, Xu Jianhua, Zhang Li, Shuai Zongwen, Pan Faming

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University , Hefei, Anhui , P. R. China.

出版信息

Mod Rheumatol. 2014 Nov;24(6):985-91. doi: 10.3109/14397595.2014.894489. Epub 2014 Mar 27.

DOI:10.3109/14397595.2014.894489

PMID:24673577

Abstract

OBJECTIVES

Published association studies of killer cell immunoglobulin-like receptors (KIRs) and ankylosing spondylitis (AS) in populations are inconsistent. The aim of this study is to determine whether the KIR polymorphisms confer susceptibility to AS in populations by conducting a meta-analysis.

METHODS

A computer search was carried out up to August 2013 for literature pertaining to AS and KIR polymorphisms. Publications addressing the association between the KIR polymorphisms and susceptibility to AS in populations were selected from the Pubmed, Elsevier Science Direct, China National Knowledge Infrastructure (CNKI) and Chinese Biomedical Literature Database (CBM) databases. The odds ratio (OR) with 95% confidence interval (95%CI) was calculated.

RESULTS

A total of 13 case-control studies in 9 articles were included in this meta-analysis. Meta-analysis results identified two positive associations of 2DS4 and 3DS1 with susceptibility to AS in populations. In subgroup analysis, there was a positive association between 2DS4 and susceptibility to AS in Asians, but not in Caucasians. And there were associations between 3DL1, 3DS1 and susceptibility to AS in Caucasians, but not in Asians. Results of subgroup analysis also showed that there were associations between 2DL5, 2DS4, 2DS5, 3DL1, 3DS1 and susceptibility to AS in HLA-B27-positive patients and HLA-B27-positive healthy controls.

CONCLUSIONS

This meta-analysis confirms that 2DS4 and 3DS1 might be potential risk factors for AS in populations.

摘要

目的

已发表的关于人群中杀伤细胞免疫球蛋白样受体（KIRs）与强直性脊柱炎（AS）的关联研究结果并不一致。本研究旨在通过荟萃分析确定KIR基因多态性是否会使人群易患AS。

方法

截至2013年8月，通过计算机检索与AS和KIR基因多态性相关的文献。从PubMed、爱思唯尔科学Direct、中国知网（CNKI）和中国生物医学文献数据库（CBM）中筛选出关于KIR基因多态性与人群AS易感性之间关联的出版物。计算比值比（OR）及其95%置信区间（95%CI）。

结果

本荟萃分析共纳入9篇文章中的13项病例对照研究。荟萃分析结果确定了2DS4和3DS1与人群AS易感性之间的两个阳性关联。在亚组分析中，2DS4与亚洲人AS易感性之间存在阳性关联，而在白种人中不存在。3DL1、3DS1与白种人AS易感性之间存在关联，但亚洲人中不存在。亚组分析结果还显示，2DL5、2DS4、2DS5、3DL1、3DS1与HLA-B27阳性患者及HLA-B27阳性健康对照者的AS易感性之间存在关联。