Rheumatology Research Center, Tehran University of Medical Sciences, PO Box: 1411713137, Tehran, Iran.
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
BMC Med Genet. 2019 Jan 29;20(1):24. doi: 10.1186/s12881-019-0754-6.
Currently published studies investigating association between the killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and rheumatoid arthritis (RA) reported inconsistent and contradictory results. Hence, we aim to carry out this comprehensive meta-analysis of all eligible studies meeting the inclusion criteria to achieve precise and comprehensive relationships between genetic variations in KIR gene cluster and risk of RA.
Databases of Medline/PubMed and Scopus were searched to investigate case-control studies prior to May 2018. The associations between KIR gene polymorphisms and RA susceptibility were analyzed by computing the odds ratio (OR) and 95% confidence interval (95% CI) for each study.
A total of 11 comparative case-control studies involving 1847 RA patients and 2409 healthy individuals were included in this meta-analysis. Four significant associations of 2DL3 (OR = 0.591, 95% CI = 0.351-0.994; P = 0.047), 2DL5 (OR = 0.716, 95% CI = 0.601-0.853; P < 0.001), 2DS5 (OR = 0.623, 95% CI = 0.393-0.988; P = 0.045), and 3DL3 (OR = 0.324, 95% CI = 0.129-0.814; P = 0.016) genes with decreased RA risk were discovered in this meta-analysis. Although, other KIR receptors including 2DL1, 2DL2, 2DL4, 3DL1, 3DL2, 3DS1, 2DS1-2DS4, and two pseudo gens of 2DP1 and 3DP1 displayed no significant association with predisposition to RA.
These findings provide reliable evidence that 2DL3, 2DL5, 3DL3, and 2DS5 might have a potential protective role for RA.
目前发表的研究调查了杀伤细胞免疫球蛋白样受体（KIR）基因多态性与类风湿关节炎（RA）之间的关联，这些研究结果不一致且相互矛盾。因此，我们旨在进行这项全面的荟萃分析，以评估符合纳入标准的所有研究，以获得 KIR 基因簇遗传变异与 RA 风险之间的精确和全面关系。
在 2018 年 5 月之前，我们检索了 Medline/PubMed 和 Scopus 数据库，以调查病例对照研究。通过计算每个研究的优势比（OR）和 95％置信区间（95％CI），分析 KIR 基因多态性与 RA 易感性之间的关系。
本荟萃分析共纳入了 11 项比较病例对照研究，共纳入 1847 例 RA 患者和 2409 名健康对照者。结果发现，2DL3（OR=0.591，95％CI=0.351-0.994；P=0.047）、2DL5（OR=0.716，95％CI=0.601-0.853；P<0.001）、2DS5（OR=0.623，95％CI=0.393-0.988；P=0.045）和 3DL3（OR=0.324，95％CI=0.129-0.814；P=0.016）基因与降低 RA 风险显著相关。然而，其他 KIR 受体，包括 2DL1、2DL2、2DL4、3DL1、3DL2、3DS1、2DS1-2DS4，以及 2DP1 和 3DP1 的两个假基因，与 RA 易感性无显著相关性。
这些发现为 2DL3、2DL5、3DL3 和 2DS5 对 RA 可能具有潜在的保护作用提供了可靠的证据。
