Rezaei Ramazan, Mostafaei Shayan, Aslani Saeed, Jamshidi Ahmadreza, Mahmoudi Mahdi
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Int J Rheum Dis. 2018 Oct;21(10):1746-1755. doi: 10.1111/1756-185X.13408. Epub 2018 Nov 5.
Several genetic studies have assessed the association between polymorphisms in killer immunoglobulin-like receptors (KIR) genes and susceptibility of individuals to ankylosing spondylitis (AS), but the findings have been inconclusive and incongruous. Therefore, we conducted this meta-analysis of all case-control studies meeting the inclusion criteria for obtaining an exact conclusion of the effect of KIR polymorphisms on the risk of AS.
A systematic literature search was conducted in electronic databases, including Scopus web of science, ScienceDirect, and PubMed to find all eligible studies exploring the association between KIR polymorphisms and the risk of AS, prior to June 2017. Pooled odds ratios (OR) and their corresponding 95% CIs were used to evaluate the strength of the association between KIR polymorphisms and the risk of AS.
A total of 16 case-control studies, encompassed in 12 papers, with 1770 cases and 2907 healthy subjects were included in the meta-analysis. This meta-analysis revealed three significant positive associations of 2DS1, 2DS5, and 3DS1 with susceptibility to AS, while two significant negative associations of 2DL2 and 2DS2 with susceptibility to AS were identified. In the subgroup analysis based on human leukocyte antigen (HLA)-B27 positive patients and healthy subjects, results indicated that there were four significant positive associations between 2DL5, 2DS4, 2DS5, 3DS1 polymorphisms and susceptibility to AS in HLA-B27-positive patients; a significant negative association of 3DL1 in HLA-B*27-positive patients was found.
While 2DS1, 2DS5, and 3DS1 polymorphisms increased AS risk, 2DL2 and 2DS2 polymorphisms were associated with reduced AS susceptibility.
多项基因研究评估了杀伤细胞免疫球蛋白样受体（KIR）基因多态性与个体患强直性脊柱炎（AS）易感性之间的关联，但研究结果尚无定论且不一致。因此，我们对所有符合纳入标准的病例对照研究进行了这项荟萃分析，以准确得出KIR基因多态性对AS风险影响的结论。
在电子数据库中进行系统的文献检索，包括Scopus科学网、ScienceDirect和PubMed，以查找2017年6月之前所有探讨KIR基因多态性与AS风险关联的符合条件的研究。采用合并比值比（OR）及其相应的95%置信区间（CI）来评估KIR基因多态性与AS风险之间关联的强度。
荟萃分析共纳入了12篇论文中的16项病例对照研究，包括1770例病例和2907名健康受试者。这项荟萃分析揭示了2DS1、2DS5和3DS1与AS易感性之间存在三项显著的正相关，同时确定了2DL2和2DS2与AS易感性之间存在两项显著的负相关。在基于人类白细胞抗原（HLA）-B27阳性患者和健康受试者的亚组分析中，结果表明在HLA-B27阳性患者中，2DL5、2DS4、2DS5、3DS1基因多态性与AS易感性之间存在四项显著的正相关；在HLA-B*27阳性患者中发现了3DL1的一项显著负相关。
虽然2DS1、2DS5和3DS1基因多态性增加了AS风险，但2DL2和2DS2基因多态性与AS易感性降低有关。
