Roch J M, Tosic M, Roach A, Matthieu J M
Schweiz Arch Neurol Psychiatr (1985). 1989;140(1):6-10.
Myelin-deficient (mld) mice present two tandem myelin basic protein genes, with the upstream gene containing an inversion (Popko et al., Neuron 1: 221, 1988). Detailed analysis of the transcriptional activity of various regions of the gene showed that all portions of the MBP gene are transcribed in mld mice. Consequently, we propose that the low levels of MPB mRNA observed in mld mice are due to post-transcriptional events.
髓磷脂缺陷（mld）小鼠有两个串联的髓磷脂碱性蛋白基因，上游基因存在一个倒位（波普科等人，《神经元》1:221，1988年）。对该基因不同区域转录活性的详细分析表明，MBP基因的所有部分在mld小鼠中都有转录。因此，我们认为在mld小鼠中观察到的低水平MPB mRNA是转录后事件所致。
