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二嗪农毒性:对斑马鱼(鲤科)肝脏中蛋白质和核酸代谢的影响

Diazinon toxicity: effect on protein and nucleic acid metabolism in the liver of zebrafish, Brachydanio rerio (Cyprinidae).

作者信息

Ansari B A, Kumar K

机构信息

Department of Zoology, University of Gorakhpur, India.

出版信息

Sci Total Environ. 1988 Sep 15;76(1):63-8. doi: 10.1016/0048-9697(88)90284-7.

DOI:10.1016/0048-9697(88)90284-7
PMID:2467376
Abstract

Four-month old adult siblings of zebrafish were exposed to four concentrations of diazinon for up to 168 h. DNA, RNA, protein and total free amino acid content were monitored in the liver. The DNA, RNA and protein contents were significantly reduced, whereas the amino acid content was significantly enhanced. All these changes showed dose- as well as time-dependent response.

摘要

将四个月大的斑马鱼成年同胞暴露于四种浓度的二嗪农中长达168小时。监测肝脏中的DNA、RNA、蛋白质和总游离氨基酸含量。DNA、RNA和蛋白质含量显著降低,而氨基酸含量显著增加。所有这些变化均呈现出剂量和时间依赖性反应。

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引用本文的文献

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The state of the art of the zebrafish model for toxicology and toxicologic pathology research--advantages and current limitations.用于毒理学和毒理病理学研究的斑马鱼模型的现状——优势与当前局限性
Toxicol Pathol. 2003 Jan-Feb;31 Suppl(Suppl):62-87. doi: 10.1080/01926230390174959.