Phillips Kathryn, Keane Kathleen, Wolfe Barbara E
Fairfield University, Fairfield, CT.
Boston College, Chestnut Hill, MA; Richards 1, Maine Medical Center, Portland, ME.
Arch Psychiatr Nurs. 2014 Apr;28(2):108-13. doi: 10.1016/j.apnu.2013.11.006. Epub 2013 Nov 23.
Currently, there is limited understanding of the etiology of BN. While multifaceted etiology is likely, several neurobiological factors may play a role. Brain derived neurotrophic factor (BDNF), a potential biomarker linked to eating and weight disorders, is one factor of recent investigation. This paper examined studies comparing BDNF blood levels in BN to healthy control (HC) subjects.
A systematic review of the literature was conducted utilizing five databases (PubMed, CINAHL, EMBASE, PsycINFO, and Medline). Key terms included eating disorders, BDNF, and bulimia nervosa.
BDNF blood levels appear lower in BN than in HC subjects; however, studies are needed to examine the influence of possible correlates including symptom severity, mood, medications, exercise, and substance use.
目前，对于神经性贪食症（BN）的病因了解有限。虽然其病因可能是多方面的，但一些神经生物学因素可能起作用。脑源性神经营养因子（BDNF）是一种与饮食和体重紊乱相关的潜在生物标志物，是近期研究的一个因素。本文考察了比较神经性贪食症患者与健康对照（HC）受试者血液中BDNF水平的研究。
利用五个数据库（PubMed、CINAHL、EMBASE、PsycINFO和Medline）对文献进行系统综述。关键词包括饮食失调、BDNF和神经性贪食症。
神经性贪食症患者血液中的BDNF水平似乎低于健康对照受试者；然而，需要开展研究来考察可能的相关因素的影响，包括症状严重程度、情绪、药物、运动和物质使用情况。
