Liu Jia, Hau Eric, Links Matthew, Graham Peter H
Faculty of Medicine, University of NSW, New South Wales, Australia.
Prince of Wales Clinical School, University of NSW, New South Wales, Australia.
Asia Pac J Clin Oncol. 2016 Jun;12(2):e352-e355. doi: 10.1111/ajco.12184. Epub 2014 Mar 27.
Primary adenoid cystic carcinoma of the lung is a rare subtype of lung cancer with a prolonged natural history but is difficult to completely resect surgically due to its proximal location. Hence radiotherapy plays a role for local control of these cancers. The role of systemic therapies in the treatment of adenoid cystic carcinoma of the lung remains unclear. Isolated case reports have previously described the treatment of primary adenoid cystic carcinoma of the lung with tamoxifen, resulting in partial control. We report the first case of primary adenoid cystic carcinoma of the lung treated with primary chemoradiotherapy due to unresectable location of the tumor, and disease stabilization with symptomatic response to tamoxifen following tumor recurrence. There is a need for further studies to investigate the role of anti-hormonal therapies in the treatment of adenoid cystic carcinoma of the lung.
原发性肺腺样囊性癌是肺癌的一种罕见亚型，其自然病程较长，但由于其位置靠近近端，手术难以完全切除。因此，放疗在这些癌症的局部控制中发挥着作用。全身治疗在肺腺样囊性癌治疗中的作用仍不明确。此前有个别病例报告描述了用他莫昔芬治疗原发性肺腺样囊性癌，取得了部分控制效果。我们报告了首例因肿瘤位置无法切除而接受原发放化疗的原发性肺腺样囊性癌病例，肿瘤复发后使用他莫昔芬治疗症状得到缓解且病情稳定。有必要进一步研究抗激素疗法在肺腺样囊性癌治疗中的作用。
