Yu Tao, Guo Ping, Wu Yingying, Zhao Jiafeng, Wu Lichun, Li Chunhua, Liu Kun, Zhu Guiquan, Chen Jin, Xu Chuan, Cai Yongcong, Liu Jifeng, Wang Zhaohui
Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041 Sichuan People's Republic Ofchina.
Springerplus. 2015 Nov 12;4:698. doi: 10.1186/s40064-015-1485-6. eCollection 2015.
The "Cancer Immunoediting" concept has provided critical insights suggesting dual functions of immune system during the cancer initiation and development. However, the dynamics and roles of CD4(+) and CD8(+) T cells, CD19(+) B cells, and CD56(+) NK cells in the patients with oral squamous cell carcinoma during treatment remain unclear. A total of 43 patients with OSCC were divided into different groups according to different clinical factors (TNM staging, pathological patterns, age and genders) for assessment of relations with CD3(+)CD4(+) T cells, CD3(+)CD8(+) T cells, CD3(-)CD19(+) B cells and CD3(-)CD16(+)CD56(+) NK cells and different chemotherapy and radical operation. The expression of CD3(+)CD4(+) T cells were significantly increased in advanced tumor stage, large tumor size and positive lymph nodes metastasis, compared to that in early groups. The accumulation of CD3(+)CD4(+) T cells were significantly increased in OSCC patients received 2 cycles CT and radical operation. Moreover, the accumulation of CD3(+)CD8(+) T cells were significantly decreased in OSCC patients received 2 cycles CT and radical operation. The distribution of circulating CD3(-)CD19(+) B cells was related with radical operation in patients with OSCC. This study indicate that CD4(+) T cells have opposing roles in OSCC progression and outcomes, which provides new insights relevant for the development of effective cancer immunotherapeutic approaches. 2 cycles TP regime chemotherapy and radical therapy may contribute to increase the effects of anti-tumor immunity on patients with OSCC.
“癌症免疫编辑”概念为免疫系统在癌症发生和发展过程中的双重功能提供了重要见解。然而，口腔鳞状细胞癌患者在治疗过程中CD4(+)和CD8(+) T细胞、CD19(+) B细胞以及CD56(+) NK细胞的动态变化和作用仍不清楚。根据不同临床因素（TNM分期、病理类型、年龄和性别）将43例口腔鳞状细胞癌患者分为不同组，以评估其与CD3(+)CD4(+) T细胞、CD3(+)CD8(+) T细胞、CD3(-)CD19(+) B细胞以及CD3(-)CD16(+)CD56(+) NK细胞的关系，以及不同化疗和根治性手术的情况。与早期组相比，晚期肿瘤阶段、肿瘤体积大以及淋巴结转移阳性患者中CD3(+)CD4(+) T细胞的表达显著增加。接受2周期化疗和根治性手术的口腔鳞状细胞癌患者中CD3(+)CD4(+) T细胞的聚集显著增加。此外，接受2周期化疗和根治性手术的口腔鳞状细胞癌患者中CD3(+)CD8(+) T细胞的聚集显著减少。循环CD3(-)CD19(+) B细胞的分布与口腔鳞状细胞癌患者的根治性手术有关。本研究表明，CD4(+) T细胞在口腔鳞状细胞癌进展和预后中具有相反作用，这为开发有效的癌症免疫治疗方法提供了新的见解。2周期TP方案化疗和根治性治疗可能有助于增强对口腔鳞状细胞癌患者的抗肿瘤免疫效果。
