利用电子自旋共振技术对二氧化钛纳米颗粒诱导毒性的机制进行表征。
Mechanistic characterization of titanium dioxide nanoparticle-induced toxicity using electron spin resonance.
机构信息
Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA; Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA.
Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.
出版信息
J Food Drug Anal. 2014 Mar;22(1):76-85. doi: 10.1016/j.jfda.2014.01.006. Epub 2014 Jan 29.
Titanium dioxide nanoparticles (TiO(2) NPs) are one of the most widely used nanomaterials that have been manufactured worldwide and applied in different commercial realms. The well-recognized ability of TiO(2) to promote the formation of reactive oxygen species (ROS) has been extensively studied as one of the important mechanisms underlying TiO(2) NPs toxicity. As the "gold standard" method to quantify and identify ROS, electron spin resonance (ESR) spectroscopy has been employed in many studies aimed at evaluating TiO(2) NPs safety. This review aims to provide a thorough discussion of current studies using ESR as the primary method to unravel the mechanism of TiO(2) NPs toxicity. ESR spin label oximetry and immune-spin trapping techniques are also briefly introduced, because the combination of spin trapping/labeling techniques offers a promising tool for studying the oxidative damage caused by TiO(2) NPs.
二氧化钛纳米颗粒（TiO2 NPs）是世界范围内广泛制造并应用于不同商业领域的最常用纳米材料之一。TiO2 促进活性氧物质（ROS）形成的能力已被广泛研究，作为 TiO2 NPs 毒性的重要机制之一。作为定量和识别 ROS 的“金标准”方法，电子自旋共振（ESR）光谱已被用于许多旨在评估 TiO2 NPs 安全性的研究中。本综述旨在深入讨论当前使用 ESR 作为主要方法来阐明 TiO2 NPs 毒性机制的研究。ESR 自旋标记血氧测定法和免疫自旋捕获技术也被简要介绍，因为自旋捕获/标记技术的结合为研究 TiO2 NPs 引起的氧化损伤提供了一种有前途的工具。
Zotero 插件