纳米材料的神经毒性。
Neurotoxicity of nanoscale materials.
机构信息
Nanotechnology Core Facility, Office of Scientific Coordination, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
School of Public Health, Shanxi Medical University, 56 XinJian South Road, Taiyuan 030001, China.
出版信息
J Food Drug Anal. 2014 Mar;22(1):147-160. doi: 10.1016/j.jfda.2014.01.012. Epub 2014 Feb 4.
Abstract
Nanotechnology has been applied in consumer products and commercial applications, showing a significant impact on almost all industries and all areas of society. Significant evidence indicates that manufactured nanomaterials and combustion-derived nanomaterials elicit toxicity in humans exposed to these nanomaterials. The interaction of the engineered nanomaterials with the nervous system has received much attention in the nanotoxicology field. In this review, the biological effects of metal, metal oxide, and carbon-based nanomaterials on the nervous system are discussed from both in vitro and in vivo studies. The translocation of the nanoparticles through the blood-brain barrier or nose to brain via the olfactory bulb route, oxidative stress, and inflammatory mechanisms of nanomaterials are also reviewed.
摘要
纳米技术已应用于消费产品和商业应用领域，对几乎所有行业和社会领域都产生了重大影响。有重要证据表明，制造的纳米材料和燃烧衍生的纳米材料会对接触这些纳米材料的人造成毒性。在纳米毒理学领域，工程纳米材料与神经系统的相互作用受到了广泛关注。在这篇综述中，讨论了金属、金属氧化物和基于碳的纳米材料对神经系统的体内和体外研究的生物学效应。还综述了纳米材料通过血脑屏障或嗅球途径穿透血脑屏障或穿透鼻子进入大脑、氧化应激和炎症机制。
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