Kim Jung-Soo, Cha Jae-Kook, Cho Ah-Ran, Kim Min-Soo, Lee Jung-Seok, Hong Ji-Youn, Choi Seong-Ho, Jung Ui-Won
Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University, Seoul, South Korea.
Department of Periodontology, School of Dentistry, Kyung Hee University, Seoul, South Korea.
Clin Implant Dent Relat Res. 2015 Dec;17(6):1103-13. doi: 10.1111/cid.12223. Epub 2014 Mar 28.
The objective of this study was to determine the effectiveness of collagenated biphasic calcium phosphate (CBCP) as a carrier for bone morphogenetic protein-2 (BMP-2) at the early stage of healing in rabbit sinus.
In 16 rabbits, BMP-2-loaded CBCP was grafted into one sinus (the BMP group) and saline-soaked CBCP was grafted into another sinus (the CTL group). The groups were assigned randomly. After 2 weeks (n = 8) or 4 weeks (n = 8), radiographic and histological analysis was performed.
Total augmented volume was significantly larger in the BMP group at both healing periods. Furthermore, new bone volume was significantly greater in the BMP group at 4 weeks. Marked bone formation near the schneiderian membrane was found in the BMP groups at the early healing period. At 4 weeks, evenly distributed new bone was observed in the BMP group, whereas the new bone was sparsely distributed in the central portion in the CTL group.
It can be concluded that the addition of BMP-2 to CBCP resulted in a greater initial augmented volume as a result of postoperative swelling, which is replaced by early bone formation, and it was prominent near the Schneiderian membrane.
本研究的目的是确定胶原双相磷酸钙（CBCP）作为骨形态发生蛋白-2（BMP-2）载体在兔鼻窦愈合早期的有效性。
将负载BMP-2的CBCP植入16只兔子的一个鼻窦（BMP组），将盐水浸泡的CBCP植入另一个鼻窦（CTL组）。两组随机分配。在2周（n = 8）或4周（n = 8）后，进行影像学和组织学分析。
在两个愈合期，BMP组的总增容体积均显著更大。此外，BMP组在4周时的新骨体积显著更大。在愈合早期，BMP组在筛窦黏膜附近发现明显的骨形成。在4周时，BMP组观察到新骨均匀分布，而CTL组的新骨在中央部分分布稀疏。
可以得出结论，在CBCP中添加BMP-2会因术后肿胀而导致更大的初始增容体积，随后被早期骨形成所取代，且在筛窦黏膜附近尤为明显。
