Sohn Byungjin, Hwang Minkyoon, Kim Sungtae, Kim Hyeong-Il, Ku Young
Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.
Department of Restorative Dentistry, University at Buffalo School of Dental Medicine, Buffalo, NY, USA.
J Periodontal Implant Sci. 2017 Dec;47(6):381-387. doi: 10.5051/jpis.2017.47.6.381. Epub 2017 Dec 31.
The aim of this study was to evaluate volumetric and histologic changes in edentulous alveolar ridge areas after ridge preservation using basic fibroblast growth factor-2 (bFGF-2) in combination with collagenated biphasic calcium phosphate (BCP).
The experiments were performed in 6 adult male beagle dogs. The following 3 groups were created: 1) ridge preservation with bFGF-2 and collagenated BCP (experimental group), 2) ridge preservation with collagenated BCP (positive control group), and 3) a negative control group in which no ridge preservation procedure was performed. Volumetric change analysis was performed using an optical scanner and casts. Histological observations were made using light microscopy.
After the initial swelling subsided, the magnitude of the volumetric change in the experimental group and positive control group was smaller than in the negative control group. In the experimental group, a distinct trend was observed for the resorption of residual bone and collagen fibers at 4 weeks and for more mature bone and faster healing at 12 weeks.
Based on the findings of the present study, bFGF-2 may be considered for use as a therapeutic molecule in ridge preservation procedures.
本研究旨在评估在无牙牙槽嵴区域使用碱性成纤维细胞生长因子-2（bFGF-2）联合胶原化双相磷酸钙（BCP）进行牙槽嵴保存后，牙槽嵴的体积和组织学变化。
在6只成年雄性比格犬身上进行实验。设立以下3组：1）使用bFGF-2和胶原化BCP进行牙槽嵴保存（实验组），2）使用胶原化BCP进行牙槽嵴保存（阳性对照组），3）未进行牙槽嵴保存程序的阴性对照组。使用光学扫描仪和模型进行体积变化分析。使用光学显微镜进行组织学观察。
初始肿胀消退后，实验组和阳性对照组的体积变化幅度小于阴性对照组。在实验组中，观察到在4周时残余骨和胶原纤维有明显的吸收趋势，在12周时有更成熟的骨和更快的愈合。
基于本研究的结果，bFGF-2可被考虑用作牙槽嵴保存程序中的治疗分子。
