一名因携带vanA粪肠球菌导致菌血症的患者体内，克隆复合体17的vanA和vanB粪肠球菌发生共定植。
Co-colonization of vanA and vanB Enterococcus faecium of clonal complex 17 in a patient with bacteremia due to vanA E. faecium.
作者信息
Seol Chang Ahn, Park Jeong Su, Sung Heungsup, Kim Mi-Na
机构信息
Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
出版信息
Diagn Microbiol Infect Dis. 2014 Jun;79(2):141-3. doi: 10.1016/j.diagmicrobio.2014.02.018. Epub 2014 Mar 3.
A 53-year-old Vietnamese man with liver cirrhosis was transferred from a Vietnamese hospital to our tertiary care hospital in Korea in order to undergo a liver transplantation. Bacteremia due to vanA Enterococcus faecium was diagnosed, and stool surveillance cultures for vancomycin-resistant enterococci (VRE) were positive for both vanA and vanB E. faecium. Pulsed-field gel electrophoresis analysis revealed that the 2 vanA VRE isolates from the blood and stool were clonal, but the vanB VRE was unrelated to the vanA VRE. vanA and vanB VRE were ST64 and ST18, single-allele variations of clonal complex 17, respectively. This is the first case report of vanA VRE bacteremia in a Vietnamese patient and demonstrates the reemergence of vanB VRE since a single outbreak occurred 15years ago in Korea. The reemergence of vanB VRE emphasizes the importance of VRE genotyping to prevent the spread of new VRE strains.
一名53岁的越南肝硬化男子从越南一家医院转至韩国我们的三级护理医院，以便接受肝移植。诊断出粪肠球菌vanA导致的菌血症，耐万古霉素肠球菌（VRE）的粪便监测培养显示，粪肠球菌的vanA和vanB均呈阳性。脉冲场凝胶电泳分析显示，血液和粪便中的2株vanA VRE分离株是克隆性的，但vanB VRE与vanA VRE无关。vanA和vanB VRE分别为ST64和ST18，是克隆复合体17的单等位基因变异。这是越南患者中vanA VRE菌血症的首例病例报告，并表明自15年前韩国发生一次单一暴发以来，vanB VRE再次出现。vanB VRE的再次出现强调了VRE基因分型对于预防新的VRE菌株传播的重要性。
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