Apukhovskaia L I, Antonenko L V, Kholodova Iu D, Voziian P A, Solodova E V
Vopr Med Khim. 1988 Nov-Dec;34(6):49-53.
Structure properties and lipid-binding ability of fibrinogen and gamma-globulins were studied in blood plasma of children with rickets. Content of cholesterol and its esters, developing complexes with fibrinogen, was found to increase simultaneously with a decrease in the phospholipids, containing in the protein fraction, under conditions of the disease. Surface charge of the proteins studied, especially of fibrinogen, was altered, thus demonstrating the distinct impairments of their structure and functions. Lipid environment appears to be of importance in functional activity of these proteins.
对佝偻病患儿血浆中纤维蛋白原和γ-球蛋白的结构特性及脂质结合能力进行了研究。发现在疾病状态下，与纤维蛋白原形成复合物的胆固醇及其酯的含量增加，同时蛋白质组分中的磷脂含量减少。所研究蛋白质的表面电荷，尤其是纤维蛋白原的表面电荷发生了改变，从而表明其结构和功能受到了明显损害。脂质环境似乎对这些蛋白质的功能活性至关重要。
