Ivashkevich S P
Ukr Biokhim Zh (1978). 1980 Jan-Feb;52(1):97-102.
The lipid composition of transport and specific proteins was studied in normal state and with experimental rachitis. The amount of phospholipids in blood plasma proteins control animals is established to decrease as follows: albumins, immunoglobulins, alpha, beta-globulins, fibrinogen. The bulk of cholesterol and its ethers, lanosterol and squalenepare bound with albumins and alpha-, beta-globulins. With D-hydrovitaminosis in albumin and alpha-, beta-globulin fractions, the content of phospholipids, cholesterol, lanosterol and squalene in comparison with fibrinogen lowers considerably. An increase in the content of etherified cholesterol is characteristic of all protein fractions under conditions of this pathology. The value of the cholesterol: phospholipids molar ration with D-hypovitaminosis decreases for albumins and alpha-, beta-globulins and increases for immunoglobulins and fibrinogen. As compared to other proteins of blood plasma, with D-hypovitaminosis immunoglobulins are mostly enriched with lipids.
研究了正常状态和实验性佝偻病状态下转运蛋白和特定蛋白的脂质组成。已确定血浆蛋白对照动物中磷脂的含量按以下顺序降低：白蛋白、免疫球蛋白、α、β球蛋白、纤维蛋白原。大部分胆固醇及其醚、羊毛甾醇和角鲨烯与白蛋白和α、β球蛋白结合。在白蛋白和α、β球蛋白组分中出现维生素D缺乏症时，与纤维蛋白原相比，磷脂、胆固醇、羊毛甾醇和角鲨烯的含量显著降低。在这种病理状态下，所有蛋白组分的醚化胆固醇含量均增加。维生素D缺乏症时，白蛋白和α、β球蛋白的胆固醇：磷脂摩尔比降低，而免疫球蛋白和纤维蛋白原的该比值增加。与血浆中的其他蛋白相比，维生素D缺乏症时免疫球蛋白的脂质含量最高。
