Müller R, Klein H, Niehoff G
Zentrums Innere Medizin und Dermatologie, Medizinischen Hochschule Hannover.
Z Gesamte Inn Med. 1988 Dec 15;43(24):705-10.
Interferons are glycoproteins which exert a potent inhibitory effect on the replication of hepatitis B virus (HBV). Controlled studies of interferon treatment in patients with chronic HBV infection have shown seroconversion rates, from HBeAg positive to anti-HBe positive, 2 to 3 times higher than without treatment. No enhancement of this effect was observed using combinations of interferon with other antiviral substances. The reason for poor therapeutic response to interferon in the majority of patients with chronic hepatitis B may result from its lost virostatic activity against HBV-DNA located in the cell nucleus.
干扰素是一种糖蛋白，对乙型肝炎病毒（HBV）的复制具有强大的抑制作用。对慢性HBV感染患者进行的干扰素治疗对照研究表明，从HBeAg阳性血清转化为抗-HBe阳性的比例，比未治疗的情况高出2至3倍。未观察到干扰素与其他抗病毒物质联合使用能增强这种效果。大多数慢性乙型肝炎患者对干扰素治疗反应不佳的原因，可能是其对位于细胞核中的HBV-DNA失去了抑制病毒活性的作用。
