Beck Amanda P, Erdelyi Ildiko, Zeiss Caroline J
Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida, USA.
Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Comp Med. 2014 Apr;64(2):148-56.
Superficial decidualization of the endometrial stroma is an essential feature of the implantation stage of pregnancy in rhesus macaques and other primates. Decidualization involves proliferation of the endometrial stromal cells, with differentiation into morphologically distinct decidual cells. Previous reports involving nonpregnant rhesus monkeys have described local- ized and widespread endometrial decidualization in response to administration of progesterone and synthetic progestogens. Ectopic decidua or 'deciduosis' describes the condition in which groups of decidual cells are located outside of the endometrium, most often in the ovaries, uterus and cervix but also in various other organs. In humans, most cases of deciduosis are associated with normal pregnancy, and ectopic decidua can be found in the ovary in nearly all term pregnancies. Here we describe pronounced endometrial decidualization in 2 rhesus macaques. Both macaques had been treated long-term with medroxyprogesterone acetate for presumed endometriosis, which was confirmed in one of the macaques at postmortem examination. In one animal, florid extrauterine and peritoneal serosal decidualization was admixed multifocally with carcinomatosis from a primary colonic adenocarcinoma. Cells constituting endometrial and serosal decidualization reactions were immunopositive for the stromal markers CD10, collagen IV, smooth muscle actin, and vimentin and immunonegative for cytokeratin. In contrast, carcinomatous foci were cytokeratin-positive. To our knowledge, this report describes the first cases of serosal peritoneal decidualization in rhesus macaques. The concurrent presentation of serosal peritoneal decidualization with carcinomatosis is unique.
子宫内膜基质的浅蜕膜化是恒河猴和其他灵长类动物妊娠着床阶段的一个基本特征。蜕膜化涉及子宫内膜基质细胞的增殖，并分化为形态上不同的蜕膜细胞。先前关于未怀孕恒河猴的报道描述了在给予孕酮和合成孕激素后出现的局部和广泛的子宫内膜蜕膜化。异位蜕膜或“蜕膜病”描述的是蜕膜细胞群位于子宫内膜以外的情况，最常见于卵巢、子宫和宫颈，但也见于其他各种器官。在人类中，大多数蜕膜病病例与正常妊娠有关，几乎在所有足月妊娠的卵巢中都能发现异位蜕膜。在此，我们描述了2只恒河猴明显的子宫内膜蜕膜化。这两只恒河猴都长期接受醋酸甲羟孕酮治疗，推测患有子宫内膜异位症，其中一只在尸检时得到证实。在一只动物中，明显的子宫外和腹膜浆膜蜕膜化与原发性结肠腺癌的癌病多灶混合存在。构成子宫内膜和浆膜蜕膜化反应的细胞对基质标记物CD10、IV型胶原、平滑肌肌动蛋白和波形蛋白呈免疫阳性，对细胞角蛋白呈免疫阴性。相比之下，癌灶细胞角蛋白呈阳性。据我们所知，本报告描述了恒河猴首例浆膜腹膜蜕膜化病例。浆膜腹膜蜕膜化与癌病同时出现是独一无二的。
