Yin Xueyao, Zhou Jiaqiang, Yu Dan, Pan Qianqian, Dong Xuehong, Zheng Fenping, Li Hong
Department of Endocrinology, the Sir Run Run Shaw Hospital affiliated to Medical College of Zhejiang University, Hangzhou 310016, China. Email:
Zhonghua Nei Ke Za Zhi. 2014 Jan;53(1):13-8.
To investigate the relationship between serum uric acid (UA) level and abdominal obesity or metabolic syndrome (MS).
A total of 875 subjects, with 350 males and 525 females, aged 40-65 years old, were enrolled in this study. The clinical and biochemical data were collected and MRI was used to assess the visceral and subcutaneous adipose tissues. The relationships between UA level and abdominal obesity or MS were analyzed, and the cut-off values of UA for abdominal obesity and MS were determined.
Raised risks of abdominal obesity(OR = 4.35, 95%CI 1.91-9.90 in males; OR = 5.44, 95%CI 2.41-12.31 in females) and MS(OR = 4.47, 95%CI 2.08-9.62 in males; OR = 11.62, 95%CI 3.43-39.37 in females) were observed with the increase of UA level. The multiple logistic regression analysis showed that UA was an independent risk factor for hypertriglyceridemia(OR = 2.23, 95%CI 1.02-4.87 in males; OR = 3.04, 95%CI 1.49-6.23 in females) in all subjects and for abdominal obesity(OR = 3.23, 95%CI 1.32-7.91) and hypertension (OR = 2.35, 95%CI 1.37-4.05) in the females. Among the females, the regression line analyzed by simple correlation indicated that the UA level of 244.0 µmol/L was corresponded to the visceral adipose tissue area of 80 cm(2). The optimal cut-off point of UA for the diagnosis of MS was 258.8 µmol/L determined by the receiver operating characteristic curve.
The level of UA is closely correlated with abdominal obesity and MS in the middle-aged Chinese. The elevated UA level is an independent risk factor for abdominal obesity and MS in the female.
探讨血清尿酸（UA）水平与腹型肥胖或代谢综合征（MS）之间的关系。
本研究共纳入875名年龄在40 - 65岁之间的受试者，其中男性350名，女性525名。收集临床和生化数据，并使用磁共振成像（MRI）评估内脏和皮下脂肪组织。分析UA水平与腹型肥胖或MS之间的关系，并确定腹型肥胖和MS的UA临界值。
随着UA水平的升高，观察到腹型肥胖（男性：OR = 4.35，95%CI 1.91 - 9.90；女性：OR = 5.44，95%CI 2.41 - 12.31）和MS（男性：OR = 4.47，95%CI 2.08 - 9.62；女性：OR = 11.62，95%CI 3.43 - 39.37）的风险增加。多因素逻辑回归分析显示，在所有受试者中，UA是高甘油三酯血症的独立危险因素（男性：OR = 2.23，95%CI 1.02 - 4.87；女性：OR = 3.04，95%CI 1.49 - 6.23），在女性中是腹型肥胖（OR = 3.23，95%CI 1.32 - 7.91）和高血压（OR = 2.35，95%CI 1.37 - 4.05）的独立危险因素。在女性中，简单相关分析的回归线表明，UA水平为244.0 µmol/L时对应的内脏脂肪组织面积为80 cm²。通过受试者工作特征曲线确定，诊断MS的UA最佳临界值为258.8 µmol/L。
在中国中年人中，UA水平与腹型肥胖和MS密切相关。UA水平升高是女性腹型肥胖和MS的独立危险因素。
