Department of Health Planning Center, Nihon University Hospital, Tokyo, Japan; Department of Cardiology, Nihon University Hospital, Tokyo, Japan; Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Department of Cardiology, Nihon University Hospital, Tokyo, Japan; Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
J Cardiol. 2020 Jul;76(1):100-108. doi: 10.1016/j.jjcc.2020.01.011. Epub 2020 Feb 24.
Although the level of uric acid (UA) is higher in males, increased UA level in females was reported to be closely associated with prevalence of metabolic syndrome (Mets) leading to atherosclerotic cardiovascular disease (ASCVD). Few data exist regarding the gender diferences in relationship between the serum UA levels and cardo-metabolic risk in the Japanese population, which generally contains a lower proportion of obesity than Western populations.
This cross-sectional study was designed to investigate, by gender, the association between the serum UA level and abdominal obesity, and thereby cardio-metabolic risk i.e. presence of Mets and its components using a sample of 8567 apparently healthy subjects females: n = 3334, males: n = 5233 at the Health Planning Center of Nihon University Hospital between September 2015 and August 2016.
Receiver operating characteristic analysis was performed to reveal the accuracy of serum UA level as a predictor of abdominal obesity based on the Japanese criteria of Mets (females vs. males: area under the curve, 0.751 vs 0.609). Furthermore, the serum UA level and proportion of abdominal obesity rose with increasing age in females; in males, however, these parameters did not change in parallel with age. Furthermore, the serum UA levels in females reflected a status of cardio-metabolic risk when compared with males in a multi-logistic regression analysis. It is particularly worth noting that in the above-mentioned multivariate logistic regression analysis, the odds ratio of hyperuricemia in females was generally 1.3-2.5 times higher than that in males.
Compared with males, increased serum UA level in females might be involved in abdominal obesity and cardio-metabolic risk, possibly leading to the development of ASCVD even in a Japanese population. This may be due to gender differences affecting the development of abdominal obesity and changes in the serum UA levels with age.
UMIN (http://www.umin.ac.jp/) Study ID: UMIN000035901retrospectively registered 1 March 2018.
尽管男性尿酸（UA）水平较高，但女性 UA 水平升高与代谢综合征（Mets）的患病率密切相关，导致动脉粥样硬化性心血管疾病（ASCVD）。在日本人群中，血清 UA 水平与心脏代谢风险之间的关系存在性别差异，这方面的数据很少，而日本人群的肥胖比例普遍低于西方人群。
本横断面研究旨在通过性别分析血清 UA 水平与腹部肥胖的关系，以及由此产生的心脏代谢风险，即代谢综合征及其组分的存在，使用日本大学医院健康计划中心 2015 年 9 月至 2016 年 8 月期间的 8567 名看似健康的受试者样本（女性：n=3334，男性：n=5233）。
进行了受试者工作特征分析，以揭示血清 UA 水平作为基于日本代谢综合征标准的腹部肥胖预测指标的准确性（女性与男性：曲线下面积，0.751 比 0.609）。此外，女性的血清 UA 水平和腹部肥胖比例随年龄增长而增加；然而，在男性中，这些参数并没有随年龄的变化而平行变化。此外，在多变量逻辑回归分析中，与男性相比，女性的血清 UA 水平反映了心脏代谢风险的状况。值得注意的是，在上述多变量逻辑回归分析中，女性高尿酸血症的优势比通常为男性的 1.3-2.5 倍。
与男性相比，女性血清 UA 水平升高可能与腹部肥胖和心脏代谢风险有关，即使在日本人群中也可能导致 ASCVD 的发生。这可能是由于性别差异影响腹部肥胖的发展和血清 UA 水平随年龄的变化。
UMIN（http://www.umin.ac.jp/）注册号：UMIN000035901，于 2018 年 3 月 1 日回顾性注册。
