Department of Medical Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, People's Republic of China.
Department of Pediatric Intensive Care Unit, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Ann Thorac Surg. 2014 May;97(5):1827-37. doi: 10.1016/j.athoracsur.2013.12.044. Epub 2014 Mar 25.
The deleterious effect of perioperative allogeneic blood transfusion in patients with resected lung cancer has been controversial. We conducted this meta-analysis to answer the question of whether perioperative allogeneic blood transfusion adversely affects recurrence and survival in patients with resected lung cancer. Included were 23 studies with 6,474 patients. The result showed allogeneic blood transfusion was significantly associated with earlier recurrence and worse survival in patients with surgically resected lung cancer. We suggest transfusion policy should be stricter in lung cancer patients undergoing resection, especially with early-stage disease. Prospective large-scale studies are still warranted.
围手术期异体输血对肺癌患者的有害影响一直存在争议。我们进行了这项荟萃分析，以回答围手术期异体输血是否会对接受肺癌切除术的患者的复发和生存产生不利影响。共纳入 23 项研究，共 6474 例患者。结果表明，异体输血与接受手术切除的肺癌患者更早的复发和更差的生存显著相关。我们建议在接受切除术的肺癌患者中应更严格地控制输血策略，尤其是对于早期疾病患者。仍需要进行前瞻性大规模研究。
