Hicks Rodney W
AORN J. 2014 Apr;99(4):466-76; quiz 477-9. doi: 10.1016/j.aorn.2013.07.021.
The potential for contamination of compounded products and the resulting infections are a serious threat to patient safety. Immediate use products are used frequently in the perioperative department, and perioperative nurses should be familiar with the guidelines and practices that aim to reduce the contamination that can occur during the sterile compounding process. Four common themes lead to successful compounding: quality (eg, product identification, purity, stability, compatibility, risk level assessment), the environment (eg, using a segregated compounding area with specialized airflow capabilities, reducing particulate matter, practicing proper hand hygiene, performing gloved fingertip sampling, properly cleaning equipment and work areas), personnel activities (eg, familiarity with types of containers used and how often they can be accessed, following expiration dates and the number of times containers can be accessed), and the control process (eg, process monitoring, quality improvement). If a third-party vendor is contracted to handle compounding for a facility, perioperative personnel should be aware of the responsibilities for the facility and the vendor to ensure a quality compounding program.
复方制剂受污染的可能性以及由此引发的感染对患者安全构成严重威胁。即配即用产品在围手术期科室经常使用，围手术期护士应熟悉旨在减少无菌配制过程中可能发生污染的指南和操作规范。成功配制有四个共同主题：质量（如产品识别、纯度、稳定性、兼容性、风险水平评估）、环境（如使用具有专门气流能力的隔离配制区域、减少颗粒物、正确进行手部卫生、进行戴手套指尖采样、正确清洁设备和工作区域）、人员活动（如熟悉所用容器的类型及其可取用的频率、遵循有效期以及容器可取用的次数）以及控制过程（如过程监测、质量改进）。如果与第三方供应商签约为医疗机构处理配制工作，围手术期人员应了解医疗机构和供应商的职责，以确保有一个高质量的配制计划。
