Clinic for Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University Leipzig, Semmelweißstraße 10, 04103 Leipzig, Germany.
Clinic for Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany.
Psychiatry Res. 2014 Apr 30;222(1-2):91-9. doi: 10.1016/j.pscychresns.2014.02.010. Epub 2014 Feb 26.
Structural and metabolic alterations in prefrontal brain areas, including the subgenual (SGPFC), medial (MPFC) and dorsolateral prefrontal cortex (DLPFC), have been shown in major depressive disorder (MDD). Still it remains largely unknown how brain connectivity within these regions is altered at the level of neuronal oscillations. Therefore, the goal was to analyze prefrontal electroencephalographic phase synchronization in MDD and its changes after antidepressant treatment. In 60 unmedicated patients and 60 healthy controls (HC), a 15-min resting electroencephalogram (EEG) was recorded in subjects at baseline and in a subgroup of patients after 2 weeks of antidepressant medication. EEG functional connectivity between the SGPFC and the MPFC/DLPFC was assessed with eLORETA (low resolution brain electromagnetic tomography) by means of lagged phase synchronization. At baseline, patients revealed increased prefrontal connectivity at the alpha frequency between the SGPFC and the left DLPFC/MPFC. After treatment, an increased connectivity between the SGPFC and the right DLPFC/MPFC at the beta frequency was found for MDD. A positive correlation was found for baseline beta connectivity and reduction in scores on the Hamilton depression rating scale. MDD is characterized by increased EEG functional connectivity within frontal brain areas. These EEG markers of disturbed neuronal communication might have potential value as biomarkers.
前额叶脑区（包括前扣带回下部（SGPFC）、内侧前额叶皮层（MPFC）和背外侧前额叶皮层（DLPFC））的结构和代谢改变已在重度抑郁症（MDD）中得到证实。但目前仍不清楚这些区域内的脑连接在神经元振荡水平上是如何改变的。因此，本研究的目的是分析 MDD 患者前额叶脑电图相位同步及其在抗抑郁治疗后的变化。在 60 名未用药的患者和 60 名健康对照者（HC）中，在基线时和患者亚组中在抗抑郁药物治疗 2 周后，对受试者进行了 15 分钟的静息脑电图（EEG）记录。通过滞后相位同步，利用 eLORETA（低分辨率脑电磁断层扫描）评估 SGPFC 和 MPFC/DLPFC 之间的 EEG 功能连接。在基线时，患者在 SGPFC 和左 DLPFC/MPFC 之间的 alpha 频率下表现出增加的前额叶连接。在治疗后，MDD 患者在 beta 频率下 SGPFC 和右 DLPFC/MPFC 之间的连接增加。基线时 beta 连接与汉密尔顿抑郁量表评分的降低呈正相关。MDD 的特征是前额叶脑区的 EEG 功能连接增加。这些神经元通讯障碍的 EEG 标志物可能具有作为生物标志物的潜在价值。
