Ståhle-Bäckdahl M
Department of Dermatology, Karolinska Sjukhuset, Stockholm, Sweden.
Acta Derm Venereol. 1988;68(6):531-4.
Dry-looking skin of unknown etiology develops in a majority of patients with chronic renal failure. The hydration of the stratum corneum influences the appearance of the skin and lack of water is considered to induce roughness, e.g. in atopic dermatitis. The aim of the present study was to compare the water content in uremic and healthy skin and to evaluate the possible relationship between skin hydration and pruritus in uremic patients. Thirty-one patients, 19 with pruritus, undergoing chronic hemodialysis participated. Twelve healthy age-matched subjects served as controls. The skin of the uremic patients appeared generally xerotic, whereas the controls had normal-looking skin. The water content of the stratum corneum was recorded with the Corneometer, a capacitance-measuring device, on three different sites: the neck, the chest and the lower leg. There was a significant difference in water content between locations in all groups, the water content being highest in the neck and lowest in the leg (p less than 0.01). There was a tendency that patients with pruritus had a lower water content than patients without pruritus, but there was no significant difference between uremic patients and controls. Hence, insufficient hydration does not seem to explain the difference in skin texture between uremic patients and healthy subjects.
大多数慢性肾衰竭患者会出现病因不明的皮肤干燥。角质层的水合作用会影响皮肤外观，缺水被认为会导致皮肤粗糙，如在特应性皮炎中。本研究的目的是比较尿毒症患者和健康人皮肤的含水量，并评估尿毒症患者皮肤水合作用与瘙痒之间的可能关系。31名接受慢性血液透析的患者参与了研究，其中19名有瘙痒症状。12名年龄匹配的健康受试者作为对照。尿毒症患者的皮肤普遍显得干燥，而对照组的皮肤外观正常。使用角质层水合测定仪（一种电容测量装置）在三个不同部位记录角质层的含水量：颈部、胸部和小腿。所有组中不同部位的含水量存在显著差异，颈部含水量最高，腿部最低（p小于0.01）。有瘙痒症状的患者的含水量有低于无瘙痒症状患者的趋势，但尿毒症患者和对照组之间没有显著差异。因此，水合作用不足似乎无法解释尿毒症患者和健康受试者之间皮肤质地的差异。
