Genomics & Immunoregulation, LIMES-Institute University of Bonn, Bonn, Germany.
EMBO J. 2014 May 16;33(10):1087-8. doi: 10.1002/embj.201488178. Epub 2014 Mar 27.
Inflammation is a hallmark of many common diseases ranging from arthritis, atherosclerosis, or obesity to Alzheimer's disease and cancer. Identifying antiinflammatory mechanisms is therefore an important and timely task of modern biomedicine. In this issue of The EMBO Journal, a study conducted by Escolano and colleagues target a particular interaction site of calcineurin with NFAT in macrophages to elicit profound anti-inflammatory effects (Escolano et al, 2014).
炎症是许多常见疾病的标志，从关节炎、动脉粥样硬化或肥胖到阿尔茨海默病和癌症。因此，鉴定抗炎机制是现代生物医学的一项重要且及时的任务。在本期的《欧洲分子生物学组织杂志》中，Escolano 及其同事的研究针对钙调神经磷酸酶与巨噬细胞中 NFAT 的特定相互作用位点，引发了深刻的抗炎作用（Escolano 等人，2014 年）。
