National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Beijing 102206, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China.
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Beijing 102206, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China.
Tuberculosis (Edinb). 2014 May;94(3):245-51. doi: 10.1016/j.tube.2014.02.002. Epub 2014 Feb 12.
Host immune pressure and associated parasite immune evasion are key features of host-pathogen co-evolution. A previous study showed that human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved and thus it was deduced that M. tuberculosis lacks antigenic variation and immune evasion. Here, we selected 162 clinical M. tuberculosis complex (MTBC) isolates from China, amplified gene encoding Rv3878 and compared the sequences. The results showed that Rv3878, a conserved hypothetical alanine rich protein, is not conserved in M. tuberculosis strains and there are polymorphisms existing in the protein. The large number of amino acid changes in its T cell epitopes may reflect ongoing immune evasion.
宿主免疫压力和相关寄生虫免疫逃避是宿主-病原体共同进化的关键特征。先前的研究表明，结核分枝杆菌的人类 T 细胞表位是进化上高度保守的，因此可以推断结核分枝杆菌缺乏抗原变异和免疫逃避。在这里，我们从中国选择了 162 株临床结核分枝杆菌复合群（MTBC）分离株，扩增了编码 Rv3878 的基因，并比较了序列。结果表明，Rv3878 是一种保守的假定富含丙氨酸的蛋白，在结核分枝杆菌菌株中并不保守，并且该蛋白存在多态性。其 T 细胞表位中大量的氨基酸变化可能反映了持续的免疫逃避。
