Du Yingzhen, Li Hongxia, Qin Xuebing, Wang Yan, Zhang Zhijian, Qu Geping, Fang Xiangqun, Yu Senyang
Department of Respiratory, Nanlou Division, Chinese People's Liberation Army General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Department of Emergency, Beijing Tsinghua Changgung Hospital, Tsinghua University, Changping District, Beijing, China.
Tuberculosis (Edinb). 2018 May;110:20-25. doi: 10.1016/j.tube.2018.03.003. Epub 2018 Mar 15.
We used 335 Mycobacterium tuberculosis strains from 2010 National Epidemiologic Survey for TB in China and performed comparative sequence analysis of 38 kDa gene after amplification. From the results, we found that there were 5.07% M.tuberculosis strains that demonstrated genetic diversity of 38 kDa in China, and 2.99% strains showed polymorphism of the 38 kDa antigen, and this may be the reason for changes in the antigen produced, which may in turn cause alterations of related functions, thereby allowing immune evasion.
我们使用了来自2010年中国全国结核病流行病学调查的335株结核分枝杆菌菌株，并在扩增后对38 kDa基因进行了比较序列分析。从结果中我们发现，在中国，有5.07%的结核分枝杆菌菌株表现出38 kDa的遗传多样性，2.99%的菌株显示出38 kDa抗原的多态性，这可能是所产生抗原发生变化的原因，进而可能导致相关功能的改变，从而实现免疫逃逸。
